Gemcitabine free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 123210

CAS#: 95058-81-4 (free base)

Description: Gemcitabine is an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

Chemical Structure

Gemcitabine free base
CAS# 95058-81-4 (free base)

Theoretical Analysis

MedKoo Cat#: 123210
Name: Gemcitabine free base
CAS#: 95058-81-4 (free base)
Chemical Formula: C9H11F2N3O4
Exact Mass: 263.07176
Molecular Weight: 263.2
Elemental Analysis: C, 41.07; H, 4.21; F, 14.44; N, 15.97; O, 24.31

Price and Availability

Size Price Availability Quantity
1.0g USD 80.0 Same day
5.0g USD 150.0 Same day
10.0g USD 250.0 Same day
20.0g USD 450.0 Same day
50.0g USD 950.0 Same day
100.0g USD 1750.0 Same day
200.0g USD 3150.0 Same day
500.0g USD 4950.0 2 weeks
1.0kg USD 6950.0 2 weeks
Click to view more sizes and prices
Bulk inquiry

Related CAS #: 95058-81-4 (free base)   122111-03-9 (HCl)    

Synonym: LY-188011; LY 188011; LY188011; Abbreviations: dFdC; dFdCyd; gemcitabine;Gemzar.

IUPAC/Chemical Name: 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one


InChi Code: InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1

SMILES Code: O=C1N=C(N)C=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.0 19.0

Preparing Stock Solutions

The following data is based on the product molecular weight 263.2 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Park JO, Oh DY, Hsu C, Chen JS, Chen LT, Orlando M, Kim JS, Lim HY. Gemcitabine Plus Cisplatin for Advanced Biliary Tract Cancer: A Systematic Review. Cancer Res Treat. 2015 Jul;47(3):343-61. doi: 10.4143/crt.2014.308. Epub 2015 May 18. Review. PubMed PMID: 25989801.

2: Maeda T, Tsuchiya M, Ishii J, Koda T, Kubota Y, Katagiri T, Tamura A, Otsuka Y, Shibuya K, Kaneko H. [A case of pancreatic cancer with distant metastasis successfully resected after neoadjuvant chemotherapy with a combination of S-1 and gemcitabine]. Gan To Kagaku Ryoho. 2014 Nov;41(12):2184-6. Review. Japanese. PubMed PMID: 25731464.

3: Ding X, Chen W, Fan H, Zhu B. Cytidine deaminase polymorphism predicts toxicity of gemcitabine-based chemotherapy. Gene. 2015 Mar 15;559(1):31-7. doi: 10.1016/j.gene.2015.01.010. Epub 2015 Jan 10. Review. PubMed PMID: 25582275.

4: Wei MY, Zhuang YF, Wang WM. Gemcitabine for the treatment of patients with osteosarcoma. Asian Pac J Cancer Prev. 2014;15(17):7159-62. Review. PubMed PMID: 25227807.

5: de Sousa Cavalcante L, Monteiro G. Gemcitabine: metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer. Eur J Pharmacol. 2014 Oct 15;741:8-16. doi: 10.1016/j.ejphar.2014.07.041. Epub 2014 Jul 30. Review. PubMed PMID: 25084222.

6: Nordh S, Ansari D, Andersson R. hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: a systematic review. World J Gastroenterol. 2014 Jul 14;20(26):8482-90. doi: 10.3748/wjg.v20.i26.8482. Review. PubMed PMID: 25024604; PubMed Central PMCID: PMC4093699.

7: Li Q, Yuan Z, Yan H, Wen Z, Zhang R, Cao B. Comparison of gemcitabine combined with targeted agent therapy versus gemcitabine monotherapy in the management of advanced pancreatic cancer. Clin Ther. 2014 Jul 1;36(7):1054-63. doi: 10.1016/j.clinthera.2014.05.066. Epub 2014 Jun 27. Review. PubMed PMID: 24986485.

8: Khan MF, Gottesman S, Boyella R, Juneman E. Gemcitabine-induced cardiomyopathy: a case report and review of the literature. J Med Case Rep. 2014 Jun 23;8:220. doi: 10.1186/1752-1947-8-220. Review. PubMed PMID: 24957905; PubMed Central PMCID: PMC4086693.

9: Koga H, Miyoshi A, Nakamura J, Ide T, Kitahara K, Noshiro H. [A case of effective treatment with S-1/gemcitabine chemotherapy and resection for advanced pancreatic cancer with peritoneal dissemination]. Gan To Kagaku Ryoho. 2014 May;41(5):665-8. Review. Japanese. PubMed PMID: 24917019.

10: Borazanci E, Von Hoff DD. Nab-paclitaxel and gemcitabine for the treatment of patients with metastatic pancreatic cancer. Expert Rev Gastroenterol Hepatol. 2014 Sep;8(7):739-47. doi: 10.1586/17474124.2014.925799. Epub 2014 May 31. Review. PubMed PMID: 24882381.