CC-223
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MedKoo CAT#: 206423

CAS#: 1228013-30-6

Description: Onatasertib, also known as CC-223, is an orally available inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor CC-223 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/AKT/mTOR signaling pathway, which is frequently dysregulated in human cancers.


Chemical Structure

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CC-223
CAS# 1228013-30-6

Theoretical Analysis

MedKoo Cat#: 206423
Name: CC-223
CAS#: 1228013-30-6
Chemical Formula: C21H27N5O3
Exact Mass: 397.21139
Molecular Weight: 397.48
Elemental Analysis: C, 63.46; H, 6.85; N, 17.62; O, 12.08

Price and Availability

Size Price Availability Quantity
10.0mg USD 150.0 Same day
25.0mg USD 250.0 Same day
50.0mg USD 450.0 Same day
100.0mg USD 750.0 Same day
200.0mg USD 1250.0 Same day
500.0mg USD 1950.0 Same day
1.0g USD 3250.0 Same day
2.0g USD 5450.0 2 Weeks
5.0g USD 7950.0 2 Weeks
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Related CAS #: 1228013-30-6    

Synonym: CC-223; CC 223; CC223; Onatasertib;

IUPAC/Chemical Name: 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((1r,4r)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

InChi Key: UFKLYTOEMRFKAD-SHTZXODSSA-N

InChi Code: InChI=1S/C21H27N5O3/c1-21(2,28)17-9-4-13(10-22-17)16-11-23-19-20(25-16)26(18(27)12-24-19)14-5-7-15(29-3)8-6-14/h4,9-11,14-15,28H,5-8,12H2,1-3H3,(H,23,24)/t14-,15-

SMILES Code: OC(C)(C)C(N=C1)=CC=C1C(N=C2N3[C@@H]4CC[C@H](CC4)OC)=CN=C2NCC3=O

Appearance: Red to pink solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 397.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bendell JC, Kelley RK, Shih KC, Grabowsky JA, Bergsland E, Jones S, Martin T,
Infante JR, Mischel PS, Matsutani T, Xu S, Wong L, Liu Y, Wu X, Mortensen DS,
Chopra R, Hege K, Munster PN. A phase I dose-escalation study to assess safety,
tolerability, pharmacokinetics, and preliminary efficacy of the dual
mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or
multiple myeloma. Cancer. 2015 Oct 1;121(19):3481-90. doi: 10.1002/cncr.29422.
Epub 2015 Jul 15. PubMed PMID: 26177599.

2: Mortensen DS, Perrin-Ninkovic SM, Shevlin G, Zhao J, Packard G, Bahmanyar S,
Correa M, Elsner J, Harris R, Lee BG, Papa P, Parnes JS, Riggs JR, Sapienza J,
Tehrani L, Whitefield B, Apuy J, Bisonette RR, Gamez JC, Hickman M, Khambatta G,
Leisten J, Peng SX, Richardson SJ, Cathers BE, Canan SS, Moghaddam MF, Raymon HK,
Worland P, Narla RK, Fultz KE, Sankar S. Discovery of mammalian target of
rapamycin (mTOR) kinase inhibitor CC-223. J Med Chem. 2015 Jul 9;58(13):5323-33.
doi: 10.1021/acs.jmedchem.5b00626. Epub 2015 Jun 26. PubMed PMID: 26083478.

3: Mortensen DS, Fultz KE, Xu S, Xu W, Packard G, Khambatta G, Gamez JC, Leisten
J, Zhao J, Apuy J, Ghoreishi K, Hickman M, Narla RK, Bissonette R, Richardson S,
Peng SX, Perrin-Ninkovic S, Tran T, Shi T, Yang WQ, Tong Z, Cathers BE, Moghaddam
MF, Canan SS, Worland P, Sankar S, Raymon HK. CC-223, a Potent and Selective
Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization. Mol Cancer Ther.
2015 Jun;14(6):1295-305. doi: 10.1158/1535-7163.MCT-14-1052. Epub 2015 Apr 8.
PubMed PMID: 25855786.

4: Ashworth RE, Wu J. Mammalian target of rapamycin inhibition in hepatocellular
carcinoma. World J Hepatol. 2014 Nov 27;6(11):776-82. doi:
10.4254/wjh.v6.i11.776. Review. PubMed PMID: 25429315; PubMed Central PMCID:
PMC4243151.

(last updated: 4/19/2016)

CC-223

10.0mg / USD 150.0