BRL54443
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522356

CAS#: 57477-39-1

Description: BRL54443 is a potent 5-ht1E/1F receptor agonist.


Chemical Structure

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BRL54443
CAS# 57477-39-1

Theoretical Analysis

MedKoo Cat#: 522356
Name: BRL54443
CAS#: 57477-39-1
Chemical Formula: C14H18N2O
Exact Mass: 230.14191
Molecular Weight: 230.31
Elemental Analysis: C, 73.01; H, 7.88; N, 12.16; O, 6.95

Price and Availability

Size Price Availability Quantity
10.0mg USD 120.0 2 Weeks
25.0mg USD 190.0 2 Weeks
50.0mg USD 350.0 2 Weeks
100.0mg USD 550.0 2 Weeks
200.0mg USD 950.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2450.0 2 Weeks
2.0g USD 3450.0 2 Weeks
5.0g USD 4450.0 2 Weeks
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Synonym: BRL54443; BRL-54443; BRL 54443.

IUPAC/Chemical Name: 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol

InChi Key: WKNFADCGOAHBPG-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H18N2O/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14/h2-3,8-10,15,17H,4-7H2,1H3

SMILES Code: CN1CCC(C2=CNC3=C2C=C(O)C=C3)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 230.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nelson PM, Harrod JS, Lamping KG. 5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes. Exp Diabetes Res. 2012;2012:398406. doi: 10.1155/2012/398406. Epub 2012 Dec 30. PubMed PMID: 23346101; PubMed Central PMCID: PMC3546478.

2: Klein MT, Teitler M. Distribution of 5-ht(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study. Br J Pharmacol. 2012 Jun;166(4):1290-302. doi: 10.1111/j.1476-5381.2012.01868.x. PubMed PMID: 22260342; PubMed Central PMCID: PMC3417447.

3: Klein MT, Dukat M, Glennon RA, Teitler M. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. doi: 10.1124/jpet.111.179606. Epub 2011 Mar 21. PubMed PMID: 21422162; PubMed Central PMCID: PMC3101003.

4: Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8. doi: 10.1016/j.neuroscience.2009.10.020. Epub . PubMed PMID: 19837141.

5: Watts SW, Yang P, Banes AK, Baez M. Activation of Erk mitogen-activated protein kinase proteins by vascular serotonin receptors. J Cardiovasc Pharmacol. 2001 Oct;38(4):539-51. PubMed PMID: 11588524.

BRL54443

10.0mg / USD 120.0