WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522354
CAS#: 192927-92-7
Description: LY310762 is a 5-HT1D antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
MedKoo Cat#: 522354
Name: LY310762 HCl
CAS#: 192927-92-7
Chemical Formula: C24H28ClFN2O2
Exact Mass: 430.18
Molecular Weight: 430.95
Elemental Analysis: C, 66.89; H, 6.55; Cl, 8.23; F, 4.41; N, 6.50; O, 7.43
LY310762, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: LY310762; LY 310762; LY-310762; LY310762 HCl.
IUPAC/Chemical Name: 1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-dimethylindolin-2-one hydrochloride
InChi Key: BOCLFQZPFYNVFD-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H27FN2O2.ClH/c1-24(2)20-5-3-4-6-21(20)27(23(24)29)16-15-26-13-11-18(12-14-26)22(28)17-7-9-19(25)10-8-17;/h3-10,18H,11-16H2,1-2H3;1H
SMILES Code: O=C1N(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)C4=C(C=CC=C4)C1(C)C.[H]Cl
The following data is based on the product molecular weight 430.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: García-Pedraza JÁ, García M, Martín ML, Morán A. 5-HT(1D) receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. Vascul Pharmacol. 2015 May 21. pii: S1537-1891(15)00105-6. doi: 10.1016/j.vph.2015.05.003. [Epub ahead of print] PubMed PMID: 26003124.
2: García-Pedraza JÁ, García M, Martín ML, Morán A. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clin Exp Pharmacol Physiol. 2015 Jun;42(6):640-7. doi: 10.1111/1440-1681.12397. PubMed PMID: 25854421.
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5: Pullar IA, Boot JR, Broadmore RJ, Eyre TA, Cooper J, Sanger GJ, Wedley S, Mitchell SN. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur J Pharmacol. 2004 Jun 16;493(1-3):85-93. PubMed PMID: 15189767.