WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407109
Description: GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM). GSA-10 fits to the agonist pharmacophoric model with two hydrogen bond acceptor groups and four hydrophobic regions. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 does not recognize the classic bodipy-cyclopamine binding site. GSA-10 allows the pharmacological characterization of a novel Smo active site, which is notably not targeted to the primary cilium and strongly potentiated by forskolin and cholera toxin. GSA-10 belongs to a new class of Smo agonists and will be helpful for dissecting Hh mechanism of action, with important implications in physiology and in therapy. (Mol Pharmacol. 2013 May;83(5):1020-9)
MedKoo Cat#: 407109
Chemical Formula: C26H30N2O4
Exact Mass: 434.22056
Molecular Weight: 434.54
Elemental Analysis: C, 71.87; H, 6.96; N, 6.45; O, 14.73
GSA-10 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: GSA-10; GSA 10; GSA10;
IUPAC/Chemical Name: propyl 4-(1-hexyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
InChi Key: AIKGRMQUFFUUBA-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H30N2O4/c1-3-5-6-9-16-28-23-11-8-7-10-20(23)18-22(25(28)30)24(29)27-21-14-12-19(13-15-21)26(31)32-17-4-2/h7-8,10-15,18H,3-6,9,16-17H2,1-2H3,(H,27,29)
SMILES Code: O=C(OCCC)C1=CC=C(NC(C2=CC3=C(N(CCCCCC)C2=O)C=CC=C3)=O)C=C1
The following data is based on the product molecular weight 434.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A, Petricci E, Taddei M, Ruat M. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol. 2013 May;83(5):1020-9. doi: 10.1124/mol.112.084590. Epub 2013 Feb 28. Erratum in: Mol Pharmacol. 2013 Aug;84(2):303. PubMed PMID: 23448715.