GSA-10

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407109

CAS#: 300833-95-8

Description: GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM). GSA-10 fits to the agonist pharmacophoric model with two hydrogen bond acceptor groups and four hydrophobic regions. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 does not recognize the classic bodipy-cyclopamine binding site. GSA-10 allows the pharmacological characterization of a novel Smo active site, which is notably not targeted to the primary cilium and strongly potentiated by forskolin and cholera toxin. GSA-10 belongs to a new class of Smo agonists and will be helpful for dissecting Hh mechanism of action, with important implications in physiology and in therapy. (Mol Pharmacol. 2013 May;83(5):1020-9)


Chemical Structure

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GSA-10
CAS# 300833-95-8

Theoretical Analysis

MedKoo Cat#: 407109
Name: GSA-10
CAS#: 300833-95-8
Chemical Formula: C26H30N2O4
Exact Mass: 434.22056
Molecular Weight: 434.54
Elemental Analysis: C, 71.87; H, 6.96; N, 6.45; O, 14.73

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Synonym: GSA-10; GSA 10; GSA10;

IUPAC/Chemical Name: propyl 4-(1-hexyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

InChi Key: AIKGRMQUFFUUBA-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H30N2O4/c1-3-5-6-9-16-28-23-11-8-7-10-20(23)18-22(25(28)30)24(29)27-21-14-12-19(13-15-21)26(31)32-17-4-2/h7-8,10-15,18H,3-6,9,16-17H2,1-2H3,(H,27,29)

SMILES Code: O=C(OCCC)C1=CC=C(NC(C2=CC3=C(N(CCCCCC)C2=O)C=CC=C3)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 434.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A, Petricci E, Taddei M, Ruat M. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol. 2013 May;83(5):1020-9. doi: 10.1124/mol.112.084590. Epub 2013 Feb 28. Erratum in: Mol Pharmacol. 2013 Aug;84(2):303. PubMed PMID: 23448715.

GSA-10

5.0mg / Not available