WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407102
CAS#: 314245-33-5
Description: IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. IU1 inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). IU1 stimulates proteasome activity and substrate degradation. USP14 removes the ubiquitin chain of I-κB, therefore inducing I-κB degradation and increasing cytokine release.
MedKoo Cat#: 407102
Name: IU1
CAS#: 314245-33-5
Chemical Formula: 18H21FN2O
Exact Mass: 300.16379
Molecular Weight: 300.37
Elemental Analysis: C, 71.98; H, 7.05; F, 6.32; N, 9.33; O, 5.33
IU1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: IU1; IU-1; IU 1
IUPAC/Chemical Name: 1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethan-1-one
InChi Key: JUWDSDKJBMFLHE-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
SMILES Code: CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3
The following data is based on the product molecular weight 300.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Santos AR, Mele M, Vaz SH, Kellermayer B, Grimaldi M, Colino-Oliveira M, Rombo DM, Comprido D, Sebastião AM, Duarte CB. Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP. J Neurosci. 2015 Feb 25;35(8):3319-29. doi: 10.1523/JNEUROSCI.4521-14.2015. PubMed PMID: 25716833.
2: Xu YH, Guo NL. USP14 inhibitor IU1 prevents ventilator-induced lung injury in rats. Cell Mol Biol (Noisy-le-grand). 2014 Sep 7;60(2):50-4. PubMed PMID: 25198582.
3: Ponnappan S, Palmieri M, Sullivan DH, Ponnappan U. Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging. Mech Ageing Dev. 2013 Jan-Feb;134(1-2):53-9. doi: 10.1016/j.mad.2012.12.007. Epub 2013 Jan 3. PubMed PMID: 23291607; PubMed Central PMCID: PMC3558606.
4: Nag DK, Finley D. A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication. Virus Res. 2012 Apr;165(1):103-6. doi: 10.1016/j.virusres.2012.01.009. Epub 2012 Jan 26. PubMed PMID: 22306365.
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7: Bhuyan AK, Udgaonkar JB. Multiple kinetic intermediates accumulate during the unfolding of horse cytochrome c in the oxidized state. Biochemistry. 1998 Jun 23;37(25):9147-55. PubMed PMID: 9636061.
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