IU1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407102

CAS#: 314245-33-5

Description: IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. IU1 inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). IU1 stimulates proteasome activity and substrate degradation. USP14 removes the ubiquitin chain of I-κB, therefore inducing I-κB degradation and increasing cytokine release.


Chemical Structure

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IU1
CAS# 314245-33-5

Theoretical Analysis

MedKoo Cat#: 407102
Name: IU1
CAS#: 314245-33-5
Chemical Formula: 18H21FN2O
Exact Mass: 300.16379
Molecular Weight: 300.37
Elemental Analysis: C, 71.98; H, 7.05; F, 6.32; N, 9.33; O, 5.33

Size Price Shipping out time Quantity
5mg USD 250 2 Weeks
25mg USD 650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-08. Prices are subject to change without notice.

IU1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: IU1; IU-1; IU 1

IUPAC/Chemical Name: 1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethan-1-one

InChi Key: JUWDSDKJBMFLHE-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3

SMILES Code: CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 300.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Santos AR, Mele M, Vaz SH, Kellermayer B, Grimaldi M, Colino-Oliveira M, Rombo DM, Comprido D, Sebastião AM, Duarte CB. Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP. J Neurosci. 2015 Feb 25;35(8):3319-29. doi: 10.1523/JNEUROSCI.4521-14.2015. PubMed PMID: 25716833.

2: Xu YH, Guo NL. USP14 inhibitor IU1 prevents ventilator-induced lung injury in rats. Cell Mol Biol (Noisy-le-grand). 2014 Sep 7;60(2):50-4. PubMed PMID: 25198582.

3: Ponnappan S, Palmieri M, Sullivan DH, Ponnappan U. Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging. Mech Ageing Dev. 2013 Jan-Feb;134(1-2):53-9. doi: 10.1016/j.mad.2012.12.007. Epub 2013 Jan 3. PubMed PMID: 23291607; PubMed Central PMCID: PMC3558606.

4: Nag DK, Finley D. A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication. Virus Res. 2012 Apr;165(1):103-6. doi: 10.1016/j.virusres.2012.01.009. Epub 2012 Jan 26. PubMed PMID: 22306365.

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6: Sun XL, Jayaram HN, Gharehbaghi K, Li QJ, Xiao X, Antony AC. Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity. Cancer Res. 1999 Feb 15;59(4):940-6. PubMed PMID: 10029088.

7: Bhuyan AK, Udgaonkar JB. Multiple kinetic intermediates accumulate during the unfolding of horse cytochrome c in the oxidized state. Biochemistry. 1998 Jun 23;37(25):9147-55. PubMed PMID: 9636061.

8: Helliwell M, Vale A, Goulding R. Haemoperfusion in 'late' paracetamol poisoning. Hum Toxicol. 1981;1(1):25-30. PubMed PMID: 7348690.

9: Goodman SR, Marrs BL, Narconis RJ, Olson RE. Isolation and description of a menaquinone mutant from Bacillus licheniformis. J Bacteriol. 1976 Jan;125(1):282-9. PubMed PMID: 1245457; PubMed Central PMCID: PMC233361.

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