Boldine
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MedKoo CAT#: 600118

CAS#: 476-70-0

Description: Boldine is an alkaloid of the aporphine class that can be found in the boldo tree and in Lindera aggregata. Boldine has antioxidant activity that effectively protects against free radical induced lipid peroxidation or enzyme inactivation. In addition, it has alpha-adrenergic antagonist activities in vascular tissue, and it has also been reported to have hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.


Chemical Structure

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Boldine
CAS# 476-70-0

Theoretical Analysis

MedKoo Cat#: 600118
Name: Boldine
CAS#: 476-70-0
Chemical Formula: C19H21NO4
Exact Mass: 327.14706
Molecular Weight: 327.37
Elemental Analysis: C, 69.71; H, 6.47; N, 4.28; O, 19.55

Price and Availability

Size Price Availability Quantity
1.0g USD 135.0 2 Weeks
5.0g USD 220.0 2 Weeks
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Synonym:

IUPAC/Chemical Name: 1,10-DIMETHOXY-2,9-DIHYDROXYAPORPHINE

InChi Key: LZJRNLRASBVRRX-ZDUSSCGKSA-N

InChi Code: InChI=1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1

SMILES Code: CN([C@@](CC1=C2C=C(OC)C(O)=C1)3[H])CCC4=C3C2=C(OC)C(O)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 327.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Muthna D, Cmielova J, Tomsik P, Rezacova M. Boldine and related aporphines: from antioxidant to antiproliferative properties. Nat Prod Commun. 2013 Dec;8(12):1797-800. Review. PubMed PMID: 24555301.