Apigenin
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MedKoo CAT#: 600109

CAS#: 520-36-5

Description: Apigenin (4Â’,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool.


Chemical Structure

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Apigenin
CAS# 520-36-5

Theoretical Analysis

MedKoo Cat#: 600109
Name: Apigenin
CAS#: 520-36-5
Chemical Formula: C15H10O5
Exact Mass: 270.05282
Molecular Weight: 270.24
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60

Price and Availability

Size Price Availability Quantity
25.0mg USD 225.0 2 Weeks
50.0mg USD 450.0 2 Weeks
100.0mg USD 650.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
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Synonym: Apigenine; Chamomile; Apigenol; Spigenin; Versulin; 457Trihydroxyflavone; C.I. Natural Yellow 1

IUPAC/Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

InChi Key: KZNIFHPLKGYRTM-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

SMILES Code: O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 270.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bao YY, Zhou SH, Fan J, Wang QY. Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers. Future Oncol. 2013 Sep;9(9):1353-64. doi: 10.2217/fon.13.84. Review. PubMed PMID: 23980682.

2: Tong X, Pelling JC. Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention. Anticancer Agents Med Chem. 2013 Sep;13(7):971-8. Review. PubMed PMID: 23272913; PubMed Central PMCID: PMC3729595.

3: Lefort ÉC, Blay J. Apigenin and its impact on gastrointestinal cancers. Mol Nutr Food Res. 2013 Jan;57(1):126-44. doi: 10.1002/mnfr.201200424. Epub 2012 Nov 29. Review. PubMed PMID: 23197449.

4: Shukla S, Gupta S. Apigenin: a promising molecule for cancer prevention. Pharm Res. 2010 Jun;27(6):962-78. doi: 10.1007/s11095-010-0089-7. Epub 2010 Mar 20. Review. PubMed PMID: 20306120; PubMed Central PMCID: PMC2874462.

5: Balasubramanian S, Eckert RL. Keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):214-9. Epub 2007 Mar 30. Review. PubMed PMID: 17493651; PubMed Central PMCID: PMC2698294.

6: Patel D, Shukla S, Gupta S. Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol. 2007 Jan;30(1):233-45. Review. PubMed PMID: 17143534.

7: Lin JK, Chen YC, Huang YT, Lin-Shiau SY. Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J Cell Biochem Suppl. 1997;28-29:39-48. Review. PubMed PMID: 9589348.

Apigenin

25.0mg / USD 225.0