Andrographolide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 600108

CAS#: 5508-58-7

Description: Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Andrographolide is an extremely bitter substance extracted from the stem and leaves of A. paniculata. Andrographolide is used experimentally in different areas of research including cell signaling, immunomodulation, and stroke.


Chemical Structure

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Andrographolide
CAS# 5508-58-7

Theoretical Analysis

MedKoo Cat#: 600108
Name: Andrographolide
CAS#: 5508-58-7
Chemical Formula: C20H30O5
Exact Mass: 350.20932
Molecular Weight: 350.45
Elemental Analysis: C, 68.54; H, 8.63; O, 22.83

Size Price Shipping out time Quantity
100mg USD 140 2 Weeks
250mg USD 200 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-28. Prices are subject to change without notice.

Andrographolide purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym:

IUPAC/Chemical Name: 3-[2-[decahydro-6-hydroxy-5- (hydroxymethyl)-5,8a- dimethyl-2-methylene-1- napthalenyl]ethylidene]dihydro- 4-hydroxy-2(3H)-furanone

InChi Key: BOJKULTULYSRAS-WLRTZDKTSA-N

InChi Code: InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+

SMILES Code: O=C1OCC(O)/C1=C\CC2C(CCC3C(C)(CO)C(O)CCC23C)=C

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO.

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 350.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Yan YY, Shi GX, Shao J, Wang TM, Wang CZ. [Advance in studies on anti-infection of andrographolide and its derivatives in past 10 years]. Zhongguo Zhong Yao Za Zhi. 2013 Nov;38(22):3819-24. Review. Chinese. PubMed PMID: 24558857.

2: Zhou B, Zhang D, Wu X. Biological activities and corresponding SARs of andrographolide and its derivatives. Mini Rev Med Chem. 2013 Feb;13(2):298-309. Review. PubMed PMID: 23438057.

3: Aromdee C. Modifications of andrographolide to increase some biological activities: a patent review (2006 - 2011). Expert Opin Ther Pat. 2012 Feb;22(2):169-80. doi: 10.1517/13543776.2012.661718. Epub 2012 Feb 14. Review. PubMed PMID: 22329509.

4: Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):300-10. doi: 10.1111/j.1440-1681.2011.05633.x. Review. PubMed PMID: 22017767.

5: Qi CL, Wang LJ, Zhou XL. [Advances in study on anti-tumor mechanism of andrographolide]. Zhongguo Zhong Yao Za Zhi. 2007 Oct;32(20):2095-7. Review. Chinese. PubMed PMID: 18306735.

6: Liu X, Wang Y, Li G. [Advances in pharmacological study of andrographolide and its derivatives]. Zhong Yao Cai. 2003 Feb;26(2):135-8. Review. Chinese. PubMed PMID: 12971398.