Andrographolide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 600108

CAS#: 5508-58-7

Description: Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Andrographolide is an extremely bitter substance extracted from the stem and leaves of A. paniculata. Andrographolide is used experimentally in different areas of research including cell signaling, immunomodulation, and stroke.


Chemical Structure

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Andrographolide
CAS# 5508-58-7

Theoretical Analysis

MedKoo Cat#: 600108
Name: Andrographolide
CAS#: 5508-58-7
Chemical Formula: C20H30O5
Exact Mass: 350.20932
Molecular Weight: 350.45
Elemental Analysis: C, 68.54; H, 8.63; O, 22.83

Price and Availability

Size Price Availability Quantity
100.0mg USD 140.0 2 Weeks
250.0mg USD 200.0 2 Weeks
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Synonym:

IUPAC/Chemical Name: 3-[2-[decahydro-6-hydroxy-5- (hydroxymethyl)-5,8a- dimethyl-2-methylene-1- napthalenyl]ethylidene]dihydro- 4-hydroxy-2(3H)-furanone

InChi Key: BOJKULTULYSRAS-WLRTZDKTSA-N

InChi Code: InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+

SMILES Code: O=C1OCC(O)/C1=C\CC2C(CCC3C(C)(CO)C(O)CCC23C)=C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 350.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yan YY, Shi GX, Shao J, Wang TM, Wang CZ. [Advance in studies on anti-infection of andrographolide and its derivatives in past 10 years]. Zhongguo Zhong Yao Za Zhi. 2013 Nov;38(22):3819-24. Review. Chinese. PubMed PMID: 24558857.

2: Zhou B, Zhang D, Wu X. Biological activities and corresponding SARs of andrographolide and its derivatives. Mini Rev Med Chem. 2013 Feb;13(2):298-309. Review. PubMed PMID: 23438057.

3: Aromdee C. Modifications of andrographolide to increase some biological activities: a patent review (2006 - 2011). Expert Opin Ther Pat. 2012 Feb;22(2):169-80. doi: 10.1517/13543776.2012.661718. Epub 2012 Feb 14. Review. PubMed PMID: 22329509.

4: Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):300-10. doi: 10.1111/j.1440-1681.2011.05633.x. Review. PubMed PMID: 22017767.

5: Qi CL, Wang LJ, Zhou XL. [Advances in study on anti-tumor mechanism of andrographolide]. Zhongguo Zhong Yao Za Zhi. 2007 Oct;32(20):2095-7. Review. Chinese. PubMed PMID: 18306735.

6: Liu X, Wang Y, Li G. [Advances in pharmacological study of andrographolide and its derivatives]. Zhong Yao Cai. 2003 Feb;26(2):135-8. Review. Chinese. PubMed PMID: 12971398.