Albiflorin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 600104

CAS#: 39011-90-0

Description: Albiflorin is a natural product isolated from Paeoniae Radix. Albiflorin enhances mitochondrial function to suppress antimycin A-induced oxidative damage via the preservation of cytochrome c and cardiolipin. Albiflorin may reduce or prevent osteoblast degeneration in osteoporosis.


Chemical Structure

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Albiflorin
CAS# 39011-90-0

Theoretical Analysis

MedKoo Cat#: 600104
Name: Albiflorin
CAS#: 39011-90-0
Chemical Formula: C23H28O11
Exact Mass: 480.16316
Molecular Weight: 480.46
Elemental Analysis: C, 57.50; H, 5.87; O, 36.63

Size Price Shipping out time Quantity
1mg USD 300 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-01. Prices are subject to change without notice.

Albiflorin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym:

IUPAC/Chemical Name: [1-(|A-d-glucopyranosyloxy)-4-hydroxy-6-methyl-8-oxo-7-oxatricyclo[4.3.0.03,9]non-9-yl]methyl benzoate

InChi Key: QQUHMASGPODSIW-URSQEBIUSA-N

InChi Code: InChI=1S/C23H28O11/c1-21-8-13(25)12-7-23(21,33-19-17(28)16(27)15(26)14(9-24)32-19)22(12,20(30)34-21)10-31-18(29)11-5-3-2-4-6-11/h2-6,12-17,19,24-28H,7-10H2,1H3/t12?,13?,14-,15-,16+,17-,19-,21?,22?,23?/m1/s1

SMILES Code: O=C(OCC1(C2(O[C@@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)CC1C(O)CC2(C)O4)C4=O)C5=CC=CC=C5

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO.

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 480.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Huang X, Su S, Cui W, Liu P, Duan JA, Guo J, Li Z, Shang E, Qian D, Huang Z. Simultaneous determination of paeoniflorin, albiflorin, ferulic acid, tetrahydropalmatine, protopine, typhaneoside, senkyunolide I in Beagle dogs plasma by UPLC-MS/MS and its application to a pharmacokinetic study after Oral Administration of Shaofu Zhuyu Decoction. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jul 1;962:75-81. doi: 10.1016/j.jchromb.2014.05.032. Epub 2014 May 24. PubMed PMID: 24907546.

2: Wang QS, Gao T, Cui YL, Gao LN, Jiang HL. Comparative studies of paeoniflorin and albiflorin from Paeonia lactiflora on anti-inflammatory activities. Pharm Biol. 2014 Mar 19. [Epub ahead of print] PubMed PMID: 24646307.

3: Yan Y, Chai CZ, Wang DW, Wu J, Xiao HH, Huo LX, Zhu DN, Yu BY. Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. J Pharm Biomed Anal. 2014 Jul;95:76-84. doi: 10.1016/j.jpba.2014.02.013. Epub 2014 Mar 2. PubMed PMID: 24637051.

4: Zhang JJ, Huang YF, Wang LL, Li W, Wang JX, Wang C, Qu SS. [Comparative study on effects of blood enriching on mouse model of blood deficiency syndrome induced by compound method of bleeding, starved feeding and exhausting of Paeoniae Radix Alba and Paeoniae Radix Rubra, paeoniflorin and albiflorin]. Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3358-62. Chinese. PubMed PMID: 24422408.

5: Suh KS, Choi EM, Lee YS, Kim YS. Protective effect of albiflorin against oxidative-stress-mediated toxicity in osteoblast-like MC3T3-E1 cells. Fitoterapia. 2013 Sep;89:33-41. doi: 10.1016/j.fitote.2013.05.016. Epub 2013 May 23. PubMed PMID: 23707745.

6: Wang D, Tan QR, Zhang ZJ. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci. 2013 Oct;51(2):581-90. doi: 10.1007/s12031-013-0031-7. Epub 2013 May 22. PubMed PMID: 23695964.

7: Morinaga O, Lu Z, Lin L, Uto T, Sangmalee S, Putalun W, Tanaka H, Shoyama Y. Detection of paeoniflorin and albiflorin by immunostaining technique using anti-paeoniflorin monoclonal antibody. Phytochem Anal. 2013 Feb;24(2):124-8. doi: 10.1002/pca.2389. Epub 2012 Jul 11. PubMed PMID: 22782934.

8: Wang R, Peng X, Wang L, Tan B, Liu J, Feng Y, Yang S. Preparative purification of peoniflorin and albiflorin from peony rhizome using macroporous resin and medium-pressure liquid chromatography. J Sep Sci. 2012 Aug;35(15):1985-92. doi: 10.1002/jssc.201200120. Epub 2012 Jun 5. PubMed PMID: 22674837.

9: Seo CS, Lee MY, Lim HS, Kim SJ, Ha H, Lee JA, Shin HK. Determination of 5-hydroxymethyl-2-furfural, albiflorin, paeoniflorin, liquiritin, ferulic acid, nodakenin, and glycyrrhizin by HPLC-PDA, and evaluation of the cytotoxicity of Palmul-tang, a traditional Korean herbal medicine. Arch Pharm Res. 2012 Jan;35(1):101-8. doi: 10.1007/s12272-012-0111-1. Epub 2012 Feb 2. PubMed PMID: 22297748.

10: Xu W, Zhou L, Ma X, Chen Y, Qin B, Zhai X, You S. Therapeutic effects of combination of paeoniflorin and albiflorin from Paeonia radix on radiation and chemotherapy-induced myelosuppression in mice and rabbits. Asian Pac J Cancer Prev. 2011;12(8):2031-7. PubMed PMID: 22292646.