SB334867 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510291

CAS#: 249889-64-3 (HCl)

Description: SB334867 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX1, with around 50x selectivity for OX1 over OX2 receptors. It has been shown to produce sedative and anorectic effects in animals, and has been useful in characterising the orexinergic regulation of brain systems involved with appetite and sleep, as well as other physiological processes. Orexin antagonists have multiple potential clinical applications including the treatment of drug addiction, insomnia, obesity and diabetes.


Chemical Structure

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SB334867 HCl
CAS# 249889-64-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 510291
Name: SB334867 HCl
CAS#: 249889-64-3 (HCl)
Chemical Formula: C17H14ClN5O2
Exact Mass: 319.10692
Molecular Weight: 355.782
Elemental Analysis: C, 57.39; H, 3.97; Cl, 9.96; N, 19.68; O, 8.99

Size Price Shipping out time Quantity
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Pricing updated 2021-03-02. Prices are subject to change without notice.

SB334867 HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Related CAS #: 792173-99-0 (free base)   249889-64-3 (HCl)    

Synonym: SB334867; SB334867; SB 334867; SB334867 HCl; SB334867 hydrochloride

IUPAC/Chemical Name: 1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea hydrochloride

InChi Key: InChI=1S/C17H13N5O2.ClH/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14;/h2-9H,1H3,(H2,18,21,22,23);1H

InChi Code: InChI=1S/C17H13N5O2.ClH/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14;/h2-9H,1H3,(H2,18,21,22,23);1H

SMILES Code: O=C(NC1=CC=NC2=CC=CN=C12)NC3=CC=C4N=C(C)OC4=C3.[H]Cl

Appearance:
white to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 355.782 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Martin-Fardon R, Weiss F. N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking. Addict Biol. 2014 Mar;19(2):233-6. doi: 10.1111/j.1369-1600.2012.00480.x. Epub 2012 Jul 26. PubMed PMID: 22830647; PubMed Central PMCID: PMC3491173.

2: Yamada H, Takahashi N, Tanno S, Nagamine M, Takakusaki K, Okumura T. A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats. Neurosci Lett. 2005 Mar 11;376(2):137-42. Epub 2005 Jan 24. PubMed PMID: 15698936.



Additional Information