WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510291
CAS#: 249889-64-3 (HCl)
Description: SB334867 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX1, with around 50x selectivity for OX1 over OX2 receptors. It has been shown to produce sedative and anorectic effects in animals, and has been useful in characterising the orexinergic regulation of brain systems involved with appetite and sleep, as well as other physiological processes. Orexin antagonists have multiple potential clinical applications including the treatment of drug addiction, insomnia, obesity and diabetes.
MedKoo Cat#: 510291
Name: SB334867 HCl
CAS#: 249889-64-3 (HCl)
Chemical Formula: C17H14ClN5O2
Exact Mass: 319.10692
Molecular Weight: 355.782
Elemental Analysis: C, 57.39; H, 3.97; Cl, 9.96; N, 19.68; O, 8.99
SB334867 HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: SB334867; SB334867; SB 334867; SB334867 HCl; SB334867 hydrochloride
IUPAC/Chemical Name: 1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea hydrochloride
InChi Key: InChI=1S/C17H13N5O2.ClH/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14;/h2-9H,1H3,(H2,18,21,22,23);1H
InChi Code: InChI=1S/C17H13N5O2.ClH/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14;/h2-9H,1H3,(H2,18,21,22,23);1H
SMILES Code: O=C(NC1=CC=NC2=CC=CN=C12)NC3=CC=C4N=C(C)OC4=C3.[H]Cl
The following data is based on the product molecular weight 355.782 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Martin-Fardon R, Weiss F. N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking. Addict Biol. 2014 Mar;19(2):233-6. doi: 10.1111/j.1369-1600.2012.00480.x. Epub 2012 Jul 26. PubMed PMID: 22830647; PubMed Central PMCID: PMC3491173.
2: Yamada H, Takahashi N, Tanno S, Nagamine M, Takakusaki K, Okumura T. A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats. Neurosci Lett. 2005 Mar 11;376(2):137-42. Epub 2005 Jan 24. PubMed PMID: 15698936.