SB-202190
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510242

CAS#: 152121-30-7

Description: SB-202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. The inhibitory activity of SB 202190 on CREB phosphorylation was independent of p38, but instead correlated with inhibition of casein kinase 1 (CK1) in vitro.

Chemical Structure

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SB-202190
CAS# 152121-30-7
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 510242
Name: SB-202190
CAS#: 152121-30-7
Chemical Formula: C20H14FN3O
Exact Mass: 331.11209
Molecular Weight: 331.34
Elemental Analysis: C, 72.50; H, 4.26; F, 5.73; N, 12.68; O, 4.83

Size Price Shipping out time Quantity
500mg USD 450 2 Weeks
1g USD 850 2 Weeks
2g USD 1530 2 Weeks
5g USD 3450 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-02-27. Prices are subject to change without notice.

SB-202190, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: SB202190; SB202190; SB 202190.

IUPAC/Chemical Name: 4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)phenol

InChi Key: QHKYPYXTTXKZST-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)

SMILES Code: OC1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 331.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Glover M, Sweeny C, Davis B, O'Shaughnessy KM. A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190. Open Med Chem J. 2010 Sep 3;4:57-61. doi: 10.2174/1874104501004010057. PubMed PMID: 21249167; PubMed Central PMCID: PMC3023092.

2: Shanware NP, Williams LM, Bowler MJ, Tibbetts RS. Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190. BMB Rep. 2009 Mar 31;42(3):142-7. PubMed PMID: 19336000.

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SB-202190

500mg / USD 450


Additional Information