PEAQX sodium
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MedKoo CAT#: 510289

CAS#: 2102348-87-6 (sodium)

Description: PEAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant in animal tests.


Chemical Structure

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PEAQX sodium
CAS# 2102348-87-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 510289
Name: PEAQX sodium
CAS#: 2102348-87-6 (sodium)
Chemical Formula: C17H15BrN3Na4O6P
Exact Mass:
Molecular Weight: 560.1588
Elemental Analysis: C, 36.45; H, 2.70; Br, 14.26; N, 7.50; Na, 16.42; O, 17.14; P, 5.53

Price and Availability

Size Price Availability Quantity
100.0mg USD 1650.0 2 Weeks
200.0mg USD 2650.0 2 Weeks
500.0mg USD 3750.0 2 Weeks
1.0g USD 4650.0 2 Weeks
2.0g USD 7450.0 2 Weeks
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Related CAS #: 459836-30-7 (free acid)   2102348-87-6 (sodium)    

Synonym: NVP-AAM077; NVP-AAM 077; NVP-AAM-077; AAM-077; AAM077; AAM 077; PEAQX; PEAQX sodium; Peaqx Tetrasodium Salt

IUPAC/Chemical Name: sodium ((((S)-1-(4-bromophenyl)ethyl)amino)(2,3-dioxidoquinoxalin-5-yl)methyl)phosphonate hydrate .

InChi Key: SMGAGBKXHAHCGQ-VSYRWHDMSA-J

InChi Code: InChI=1S/C17H17BrN3O5P.4Na.H2O/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;;1H2/q;4*+1;/p-4/t9-,17?;;;;;/m0...../s1

SMILES Code: [O-]C1=NC2=C(C(P([O-])([O-])=O)N[C@H](C3=CC=C(Br)C=C3)C)C=CC=C2N=C1[O-].[H]O[H].[Na+].[Na+].[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 560.1588 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Morales M, Spear LP. The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats. Psychopharmacology (Berl). 2014 Apr;231(8):1797-807. doi: 10.1007/s00213-013-3278-3. Epub 2013 Sep 17. PubMed PMID: 24043344; PubMed Central PMCID: PMC3956710.

2: Morales M, Varlinskaya EI, Spear LP. Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats. Behav Brain Res. 2013 Aug 1;250:18-22. doi: 10.1016/j.bbr.2013.04.050. Epub 2013 May 4. PubMed PMID: 23651880; PubMed Central PMCID: PMC3700340.

3: Brittain MK, Brustovetsky T, Brittain JM, Khanna R, Cummins TR, Brustovetsky N. Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons. Neuropharmacology. 2012 Nov;63(6):974-82. doi: 10.1016/j.neuropharm.2012.07.012. Epub 2012 Jul 20. PubMed PMID: 22820271; PubMed Central PMCID: PMC3427421.

4: Bortolato M, Godar SC, Melis M, Soggiu A, Roncada P, Casu A, Flore G, Chen K, Frau R, Urbani A, Castelli MP, Devoto P, Shih JC. NMDARs mediate the role of monoamine oxidase A in pathological aggression. J Neurosci. 2012 Jun 20;32(25):8574-82. doi: 10.1523/JNEUROSCI.0225-12.2012. PubMed PMID: 22723698; PubMed Central PMCID: PMC3417343.

5: Kocsis B. Differential role of NR2A and NR2B subunits in N-methyl-D-aspartate receptor antagonist-induced aberrant cortical gamma oscillations. Biol Psychiatry. 2012 Jun 1;71(11):987-95. doi: 10.1016/j.biopsych.2011.10.002. Epub 2011 Nov 4. PubMed PMID: 22055014; PubMed Central PMCID: PMC3276718.

6: Anastasio NC, Xia Y, O'Connor ZR, Johnson KM. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91. doi: 10.1016/j.neuroscience.2009.07.058. Epub 2009 Aug 3. PubMed PMID: 19654040; PubMed Central PMCID: PMC2760688.

7: Auberson YP, Allgeier H, Bischoff S, Lingenhoehl K, Moretti R, Schmutz M. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102. PubMed PMID: 11909726.



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