WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510270
CAS#: 1270138-40-3
Description: NSI-189 is a nootropic and neurogenic research chemica. NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo.
MedKoo Cat#: 510270
Name: NSI-189
CAS#: 1270138-40-3
Chemical Formula: C22H30N4O
Exact Mass: 366.24196
Molecular Weight: 366.4998
Elemental Analysis: C, 72.10; H, 8.25; N, 15.29; O, 4.37
NSI-189 is in stock
Synonym: NSI-189; NSI 189; NSI189.
IUPAC/Chemical Name: (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone
InChi Key: DYTOQURYRYYNOR-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)
SMILES Code: O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC=CN=C3NCCC(C)C
The following data is based on the product molecular weight 366.4998 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM,
Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys
G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled,
multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in
depressed patients. Mol Psychiatry. 2016 Oct;21(10):1372-80. doi:
10.1038/mp.2015.178. PubMed PMID: 26643541; PubMed Central PMCID: PMC5030464.
2: Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM,
Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys
G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled,
multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in
depressed patients. Mol Psychiatry. 2016 Oct;21(10):1483-4. doi:
10.1038/mp.2016.140. PubMed PMID: 27528461; PubMed Central PMCID: PMC5030463