Epithalon

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510323

CAS#: 307297-39-8

Description: Epithalon is a synthetic tetra-peptide (Ala-Glu-Asp-Gly),which regulated pineal secretion processes, presumably, via protooncogenes. Epithalon showed many bioactivities, including: (1) anti-aging by activating chromatin at the old age; (2) improving eye retina condition in retinitis pigmentosa; (3) showing anticancer and anti-tumor metastatic effect; (4) preventing osmotic-stress-induced pathologic changes.


Chemical Structure

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Epithalon
CAS# 307297-39-8

Theoretical Analysis

MedKoo Cat#: 510323
Name: Epithalon
CAS#: 307297-39-8
Chemical Formula: C14H22N4O9
Exact Mass: 390.1387
Molecular Weight: 390.35
Elemental Analysis: C, 43.08; H, 5.68; N, 14.35; O, 36.89

Price and Availability

Size Price Availability Quantity
1.0g USD 2850.0 2 Weeks
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Synonym: Epithalon; AlaGluAspGly.

IUPAC/Chemical Name: (S)-4-((S)-2-aminopropanamido)-5-(((S)-3-carboxy-1-((carboxymethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid.

InChi Key: HGHOBRRUMWJWCU-FXQIFTODSA-N

InChi Code: InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1

SMILES Code: O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(NCC(O)=O)=O)=O)[C@H](C)N.

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 390.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Vinogradova IA. [Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes]. Adv Gerontol. 2009;22(4):631-8. Russian. PubMed PMID: 20405731.

2: Sibarov DA, Vol'nova AB, Frolov DS, Nozdrachev AD. Effects of intranasal administration of epitalon on neuron activity in the rat neocortex. Neurosci Behav Physiol. 2007 Nov;37(9):889-93. PubMed PMID: 17955380.

3: Sibarov DA, Vol'nova AB, Frolov DS, Nosdrachev AD. [Intranasal epitalon infusion modulates neuronal activity in the rat neocortex]. Ross Fiziol Zh Im I M Sechenova. 2006 Aug;92(8):949-56. Russian. PubMed PMID: 17217245.

4: Vinogradova IA. [Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions in rats in the course of aging]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):13-6. Russian. PubMed PMID: 17209456.

5: Rendakov NL, Tiutiunnik NN, Vinogradova IA. [Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats]. Adv Gerontol. 2006;19:72-8. Russian. PubMed PMID: 17152724.

6: Svechkina EB, Tiutiunnik NN, Vinogradova IA. [Influence of light regimens, melatonin, and epitalon on amylase activity in the pancreas and small intestine in rats of different age]. Adv Gerontol. 2006;19:66-71. Russian. PubMed PMID: 17152723.

7: Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006 Mar-Apr;20(2):253-7. PubMed PMID: 16634527.

8: Anisimov VN, Popovich IG, Zabezhinskiĭ MA, Rozenfel'd SV, Khavinson VKh, Semenchenko AV, Iashin AI. [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)]. Vopr Onkol. 2005;51(1):93-8. Russian. PubMed PMID: 15909815.

9: Kuznik BI, Pateiuk AV, Khavinson VKh, Malinin VV. [Effect of epitalon on the immunity and hemostasis in hypophysectomized chicken and old hens]. Adv Gerontol. 2004;13:90-3. Russian. PubMed PMID: 15490730.

10: Khavinson VKh, Lezhava TA, Monaselidze JR, Jokhadze TA, Dvalishvili NA, Bablishvili NK, Trofimova SV. Peptide Epitalon activates chromatin at the old age. Neuro Endocrinol Lett. 2003 Oct;24(5):329-33. PubMed PMID: 14647006.

Epithalon

10.0mg / Not available


Additional Information