WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510218
CAS#: 109909-44-6
Description: dCTP is also know as 2'-Deoxycytidine-5'-triphosphate trisodium salt.
MedKoo Cat#: 510218
Name: dCTP
CAS#: 109909-44-6
Chemical Formula: C9H16N3O13P3
Exact Mass: 466.9896
Molecular Weight: 467.15693
Elemental Analysis: C, 23.14; H, 3.45; N, 8.99; O, 44.52; P, 19.89
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: dCTP Thymus; Cytidine 5(tetrahydrogen triphosphate) 2deoxy trisodium salt; Cytidine 2deoxy 5(tetrahydrogen triphosphate) trisodium salt; Cytidine 2deoxy triphosphate trisodium salt; 2DeoxyCTP trisodium salt; 2Deoxycytidine 5triphosphate trisodium salt; 5DCTP trisodium salt; Deoxy5CTPtrisodium salt; DeoxyCTP trisodium salt; Deoxycytidine 5triphosphate trisodium salt; Deoxycytidine triphosphate trisodium salt.
IUPAC/Chemical Name: sodium ((2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl hydrogentriphosphate
InChi Key: WBIPTAOOMJEGQO-MILVPLDLSA-K
InChi Code: InChI=1S/C9H16N3O13P3.3Na/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;;/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17);;;/q;3*+1/p-3/t5-,6+,8+;;;/m0.../s1
SMILES Code: O[C@@H](C[C@H](N1C(N=C(C=C1)N)=O)O2)[C@H]2COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 467.15693 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kewn S, Hoggard PG, Sales SD, Johnson MA, Back DJ. The intracellular activation of lamivudine (3TC) and determination of 2'-deoxycytidine-5'-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells. Br J Clin Pharmacol. 2000 Dec;50(6):597-604. PubMed PMID: 11136299; PubMed Central PMCID: PMC2015020.
2: Nonaka M, Tsuchimoto D, Sakumi K, Nakabeppu Y. Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. FEBS J. 2009 Mar;276(6):1654-66. doi: 10.1111/j.1742-4658.2009.06898.x. Epub 2009 Feb 7. PubMed PMID: 19220460.
3: Zhang H, Wood OL, Papermaster SF, Nielsen CJ, Ussery MA. Palindromic oligonucleotide-directed enzymatic determination of 2'-deoxythymidine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate in human cells. Anal Biochem. 1997 Oct 1;252(1):143-52. PubMed PMID: 9324952.
4: Piall EM, Aherne GW, Marks V. The quantitative determination of 2'-deoxycytidine-5'-triphosphate in cell extracts by radioimmunoassay. Anal Biochem. 1986 Apr;154(1):276-81. PubMed PMID: 3010772.
5: Danks MK. Two simple high-performance liquid chromatographic methods for simultaneous determination of 2'-deoxycytidine 5'-triphosphate and cytosine arabinoside 5'-triphosphate concentrations in biological samples. J Chromatogr. 1982 Dec 10;233:141-8. PubMed PMID: 7161328.
6: Sagar P, Kára J. Activation of deoxycytidylate deaminase from certain embryonal and tumour tissues by 6-aza-2'-deoxycytidine-5'-monophosphate and 2'-deoxycytidine-5'-triphosphate. Folia Biol (Praha). 1966;12(1):75-9. PubMed PMID: 4288008.
