dCTP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510218

CAS#: 109909-44-6

Description: dCTP is also know as 2'-Deoxycytidine-5'-triphosphate trisodium salt.


Chemical Structure

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dCTP
CAS# 109909-44-6

Theoretical Analysis

MedKoo Cat#: 510218
Name: dCTP
CAS#: 109909-44-6
Chemical Formula: C9H16N3O13P3
Exact Mass: 466.9896
Molecular Weight: 467.15693
Elemental Analysis: C, 23.14; H, 3.45; N, 8.99; O, 44.52; P, 19.89

Size Price Shipping out time Quantity
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Pricing updated 2021-03-08. Prices are subject to change without notice.

dCTP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: dCTP Thymus; Cytidine 5(tetrahydrogen triphosphate) 2deoxy trisodium salt; Cytidine 2deoxy 5(tetrahydrogen triphosphate) trisodium salt; Cytidine 2deoxy triphosphate trisodium salt; 2DeoxyCTP trisodium salt; 2Deoxycytidine 5triphosphate trisodium salt; 5DCTP trisodium salt; Deoxy5CTPtrisodium salt; DeoxyCTP trisodium salt; Deoxycytidine 5triphosphate trisodium salt; Deoxycytidine triphosphate trisodium salt.

IUPAC/Chemical Name: sodium ((2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl hydrogentriphosphate

InChi Key: WBIPTAOOMJEGQO-MILVPLDLSA-K

InChi Code: InChI=1S/C9H16N3O13P3.3Na/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;;/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17);;;/q;3*+1/p-3/t5-,6+,8+;;;/m0.../s1

SMILES Code: O[C@@H](C[C@H](N1C(N=C(C=C1)N)=O)O2)[C@H]2COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 467.15693 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Kewn S, Hoggard PG, Sales SD, Johnson MA, Back DJ. The intracellular activation of lamivudine (3TC) and determination of 2'-deoxycytidine-5'-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells. Br J Clin Pharmacol. 2000 Dec;50(6):597-604. PubMed PMID: 11136299; PubMed Central PMCID: PMC2015020.

2: Nonaka M, Tsuchimoto D, Sakumi K, Nakabeppu Y. Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. FEBS J. 2009 Mar;276(6):1654-66. doi: 10.1111/j.1742-4658.2009.06898.x. Epub 2009 Feb 7. PubMed PMID: 19220460.

3: Zhang H, Wood OL, Papermaster SF, Nielsen CJ, Ussery MA. Palindromic oligonucleotide-directed enzymatic determination of 2'-deoxythymidine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate in human cells. Anal Biochem. 1997 Oct 1;252(1):143-52. PubMed PMID: 9324952.

4: Piall EM, Aherne GW, Marks V. The quantitative determination of 2'-deoxycytidine-5'-triphosphate in cell extracts by radioimmunoassay. Anal Biochem. 1986 Apr;154(1):276-81. PubMed PMID: 3010772.

5: Danks MK. Two simple high-performance liquid chromatographic methods for simultaneous determination of 2'-deoxycytidine 5'-triphosphate and cytosine arabinoside 5'-triphosphate concentrations in biological samples. J Chromatogr. 1982 Dec 10;233:141-8. PubMed PMID: 7161328.

6: Sagar P, Kára J. Activation of deoxycytidylate deaminase from certain embryonal and tumour tissues by 6-aza-2'-deoxycytidine-5'-monophosphate and 2'-deoxycytidine-5'-triphosphate. Folia Biol (Praha). 1966;12(1):75-9. PubMed PMID: 4288008.



Additional Information