CM-352

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510334

CAS#: 1542205-83-3

Description: CM-352 is a potent MMP inhibitor, which inhibited fibrinolysis in human whole blood functional assays and was more effective than the current standard of care, tranexamic acid, in the tail-bleeding model using a 30,000 times lower dose. Moreover, CM-352 reduced blood loss during liver hepatectomy. CM352 displayed optimal pharmacokinetic and safety profiles with no evidence of thrombosis or coagulation impairment. This novel mechanism of action, targeting MMP, defines a new class of antihemorrhagic agents without interfering with normal hemostatic function. Furthermore, CM-352 represents a pre-clinical candidate for the acute treatment of bleeding.


Chemical Structure

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CM-352
CAS# 1542205-83-3

Theoretical Analysis

MedKoo Cat#: 510334
Name: CM-352
CAS#: 1542205-83-3
Chemical Formula: C24H29N3O6S
Exact Mass: 487.17771
Molecular Weight: 487.57
Elemental Analysis: C, 59.12; H, 6.00; N, 8.62; O, 19.69; S, 6.58

Size Price Shipping out time Quantity
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Pricing updated 2021-02-28. Prices are subject to change without notice.

CM-352, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: CM352; CM 352; CM-352.

IUPAC/Chemical Name: (R)-N-hydroxy-2-((4-(4-(methylcarbamoyl)phenoxy)phenyl)sulfonyl)-8-azaspiro[4.5]decane-2-carboxamide

InChi Key: ZUZGJCNWNOCKEB-XMMPIXPASA-N

InChi Code: InChI=1S/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)/t24-/m1/s1

SMILES Code: O=C(NC)C1=CC=C(OC2=CC=C(S(=O)([C@]3(C(NO)=O)CCC4(CCNCC4)C3)=O)C=C2)C=C1.

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 487.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Orbe J, Rodriguez JA, Sanchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Paramo JA. Discovery and safety profiling of a potent pre-clinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methyl-benzamide) (CM-352), for the prevention and treatment of hemorrhage. J Med  Chem. 2015 Feb 16. [Epub ahead of print] PubMed PMID: 25686022.

CM-352

10mg / Not available


Additional Information