CM-352

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510334

CAS#: 1542205-83-3

Description: CM-352 is a potent MMP inhibitor, which inhibited fibrinolysis in human whole blood functional assays and was more effective than the current standard of care, tranexamic acid, in the tail-bleeding model using a 30,000 times lower dose. Moreover, CM-352 reduced blood loss during liver hepatectomy. CM352 displayed optimal pharmacokinetic and safety profiles with no evidence of thrombosis or coagulation impairment. This novel mechanism of action, targeting MMP, defines a new class of antihemorrhagic agents without interfering with normal hemostatic function. Furthermore, CM-352 represents a pre-clinical candidate for the acute treatment of bleeding.

Price and Availability

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Pricing updated 2020-06-05. Prices are subject to change without notice.

CM-352, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 510334
Name: CM-352
CAS#: 1542205-83-3
Chemical Formula: C24H29N3O6S
Exact Mass: 487.17771
Molecular Weight: 487.57
Elemental Analysis: C, 59.12; H, 6.00; N, 8.62; O, 19.69; S, 6.58

Synonym: CM352; CM 352; CM-352.

IUPAC/Chemical Name: (R)-N-hydroxy-2-((4-(4-(methylcarbamoyl)phenoxy)phenyl)sulfonyl)-8-azaspiro[4.5]decane-2-carboxamide

InChi Key: ZUZGJCNWNOCKEB-XMMPIXPASA-N

InChi Code: InChI=1S/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)/t24-/m1/s1

SMILES Code: O=C(NC)C1=CC=C(OC2=CC=C(S(=O)([C@]3(C(NO)=O)CCC4(CCNCC4)C3)=O)C=C2)C=C1.

Technical Data

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

Additional Information

References

1: Orbe J, Rodriguez JA, Sanchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Paramo JA. Discovery and safety profiling of a potent pre-clinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methyl-benzamide) (CM-352), for the prevention and treatment of hemorrhage. J Med Chem. 2015 Feb 16. [Epub ahead of print] PubMed PMID: 25686022.

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