WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510325
Description: AZD6642 is a potential and selective 5-Lipoxygenase activating Protein (FLAP) inhibitor. AZD6642 shows high specific potency and low lipophilicity resulting in a selective and metabolically stable profile. Based on initial PK/PD relations a low dose to human was predicted.
MedKoo Cat#: 510325
Chemical Formula: C24H27N5O3
Exact Mass: 433.21139
Molecular Weight: 433.5
Elemental Analysis: C, 66.49; H, 6.28; N, 16.16; O, 11.07
Synonym: AZD6642; AZD-6642; AZD 6642.
IUPAC/Chemical Name: (R)-5-(2-(4-(5-aminopyrazin-2-yl)phenyl)tetrahydrofuran-2-yl)-N-(2-hydroxy-2-methylpropyl)picolinamide
InChi Key: SJGLLGFHNAVMQI-XMMPIXPASA-N
InChi Code: InChI=1S/C24H27N5O3/c1-23(2,31)15-29-22(30)19-9-8-18(12-26-19)24(10-3-11-32-24)17-6-4-16(5-7-17)20-13-28-21(25)14-27-20/h4-9,12-14,31H,3,10-11,15H2,1-2H3,(H2,25,28)(H,29,30)/t24-/m1/s1
SMILES Code: O=C(C1=NC=C([C@]2(C3=CC=C(C4=NC=C(N)N=C4)C=C3)CCCO2)C=C1)NCC(C)(O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 433.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lemurell M, Ulander J, Winiwarter S, DahlÃ©n A, Davidsson O, EmtenÃ¤s H, Broddefalk J, Swanson M, Hovdal D, Plowright AT, Pettersen A, RydÃ©n-Landergren M, Barlind J, Llinas A, Herslof M, Drmota T, Sigfridsson K, Moses S, Whatling C. Discovery of AZD6642, an inhibitor of 5-Lipoxygenase Activating Protein (FLAP) for the treatment of inflammatory diseases. J Med Chem. 2014 Dec 5. [Epub ahead of print] PubMed PMID: 25478788.