AZD6642

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510325

CAS#: 1643809-54-4

Description: AZD6642 is a potential and selective 5-Lipoxygenase activating Protein (FLAP) inhibitor. AZD6642 shows high specific potency and low lipophilicity resulting in a selective and metabolically stable profile. Based on initial PK/PD relations a low dose to human was predicted.

Chemical Structure

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AZD6642
CAS# 1643809-54-4
Instruction

Theoretical Analysis

MedKoo Cat#: 510325
Name: AZD6642
CAS#: 1643809-54-4
Chemical Formula: C24H27N5O3
Exact Mass: 433.21
Molecular Weight: 433.500
Elemental Analysis: C, 66.49; H, 6.28; N, 16.16; O, 11.07

Price and Availability

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Synonym: AZD6642; AZD-6642; AZD 6642.

IUPAC/Chemical Name: (R)-5-(2-(4-(5-aminopyrazin-2-yl)phenyl)tetrahydrofuran-2-yl)-N-(2-hydroxy-2-methylpropyl)picolinamide

InChi Key: SJGLLGFHNAVMQI-XMMPIXPASA-N

InChi Code: InChI=1S/C24H27N5O3/c1-23(2,31)15-29-22(30)19-9-8-18(12-26-19)24(10-3-11-32-24)17-6-4-16(5-7-17)20-13-28-21(25)14-27-20/h4-9,12-14,31H,3,10-11,15H2,1-2H3,(H2,25,28)(H,29,30)/t24-/m1/s1

SMILES Code: O=C(C1=NC=C([C@]2(C3=CC=C(C4=NC=C(N)N=C4)C=C3)CCCO2)C=C1)NCC(C)(O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 433.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lemurell M, Ulander J, Winiwarter S, Dahlén A, Davidsson O, Emtenäs H, Broddefalk J, Swanson M, Hovdal D, Plowright AT, Pettersen A, Rydén-Landergren M, Barlind J, Llinas A, Herslof M, Drmota T, Sigfridsson K, Moses S, Whatling C. Discovery of AZD6642, an inhibitor of 5-Lipoxygenase Activating Protein (FLAP) for the treatment of inflammatory diseases. J Med Chem. 2014 Dec 5. [Epub ahead of print] PubMed PMID: 25478788.