WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510339

CAS#: 101199-38-6 (sodium)

Description: PTZ-343 is a phenothiazine (PTZ) derivative with chemical name sodium 3-(10H-phenothiazin-10-yl)propane-1-sulfonate. The free acid of PTZ-343 has molecule weight 343. For the convenience of commucation, we call it as PTZ-343. PTZ-343 is a water-soluble enhancer of luminol chemiluminescent peroxidation catalyzed by horseradish peroxidase (HRP). It acts as an electron transfer mediator, reacting with HRP-II to release HRP and a PTZ-343 radical, which oxidizes luminol anions to induce light emission.

Chemical Structure

CAS# 101199-38-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 510339
Name: PTZ-343
CAS#: 101199-38-6 (sodium)
Chemical Formula: C15H14NNaO3S2
Exact Mass: 0.00
Molecular Weight: 343.390
Elemental Analysis: C, 52.46; H, 4.11; N, 4.08; Na, 6.69; O, 13.98; S, 18.68

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Related CAS #: 101199-38-6 (sodium)   129808-92-0 (free acid)    

Synonym: PTZ343; PTZ 343; PTZ-343; PTZ-343 sodium.

IUPAC/Chemical Name: sodium 3-(10H-phenothiazin-10-yl)propane-1-sulfonate


InChi Code: InChI=1S/C15H15NO3S2.Na/c17-21(18,19)11-5-10-16-12-6-1-3-8-14(12)20-15-9-4-2-7-13(15)16;/h1-4,6-9H,5,10-11H2,(H,17,18,19);/q;+1/p-1

SMILES Code: O=S(CCCN1C2=C(C=CC=C2)SC3=CC=CC=C13)([O-])=O.[Na+]

Appearance: White solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 343.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Marzocchi, E.,Grilli, S.,Della Ciana, L., et al. Chemiluminescent detection systems of horseradish peroxidase employing nucleophilic acylation catalysts. Anal. Biochem. 377(2), 189-194 (2008).

2. Vdovenko, M.M.,Della Ciana, L. and Sakharov, I.Y. 3-(100-Phenothiazinyl)propane-1-sulfonate is a potent enhancer of soybean peroxidase-induced chemiluminescence. Anal. Biochem. 392(1), 54-58 (2009).

3. Masato. Sakaguchi , Ming. Hu , Larry. Kevan. Photoionization of alkylphenothiazines in vesicles: effects of the alkyl chain length and the vesicle surface charge. J. Phys. Chem., 1990, 94 (2), pp 870–874.