Vilazodone hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 314241

CAS#: 163521-08-2 (HCl)

Description: Vilazodone is a serotonergic antidepressant. Vilazodone was approved by the FDA for use in the United States to treat major depressive disorder in 2011. The mechanism of the antidepressant effect of vilazodone is not fully understood but is thought to be related to its enhancement of serotonergic activity in the CNS through selective inhibition of serotonin reuptake. Vilazodone is also a partial agonist at serotonergic 5-HT1A receptors; however, the net result of this action on serotonergic transmission and its role in vilazodone's antidepressant effect are unknown.

Chemical Structure

Vilazodone hydrochloride
CAS# 163521-08-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 314241
Name: Vilazodone hydrochloride
CAS#: 163521-08-2 (HCl)
Chemical Formula: C26H28ClN5O2
Exact Mass: 0.00
Molecular Weight: 477.990
Elemental Analysis: C, 65.33; H, 5.90; Cl, 7.42; N, 14.65; O, 6.69

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Related CAS #: 163521-08-2 (HCl)   163521-12-8 (free)    

Synonym: EMB-68843; EMB68843; EMB68843; Vilazodone hydrochloride; Viibryd

IUPAC/Chemical Name: 5-(4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide, hydrochloride


InChi Code: InChI=1S/C26H27N5O2.ClH/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32;/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32);1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 163521-08-2 (HCl); 163521-12-8 (free base).

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 477.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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 1: Guay DR. Vilazodone hydrochloride, a combined SSRI and 5-HT1A receptor agonist for major depressive disorder. Consult Pharm. 2012 Dec;27(12):857-67. doi: 10.4140/TCP.n.2012.857. Review. PubMed PMID: 23229074.

2: Hussar DA, Samuel J. Vilazodone hydrochloride, linagliptin, and alcaftadine. J Am Pharm Assoc (2003). 2011 Jul-Aug;51(4):557-9. doi: 10.1331/JAPhA.2011.11534. PubMed PMID: 21752782.