Methylprednisolone Acetate
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MedKoo CAT#: 300144

CAS#: 53-36-1

Description: Methylprednisolone acetate, also known as DEPO-MEDROL, is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue or intralesional injection. It is available in three strengths: 20 mg/mL; 40 mg/mL; 80 mg/mL.


Chemical Structure

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Methylprednisolone Acetate
CAS# 53-36-1

Theoretical Analysis

MedKoo Cat#: 300144
Name: Methylprednisolone Acetate
CAS#: 53-36-1
Chemical Formula: C24H32O6
Exact Mass: 416.21989
Molecular Weight: 416.50728
Elemental Analysis: C, 69.21; H, 7.74; O, 23.05

Price and Availability

Size Price Availability Quantity
100.0mg USD 550.0 2 Weeks
200.0mg USD 950.0 2 Weeks
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Synonym: Depo-Medrate; Depo-Medrin; Depo-medrol; Depomedrone; Depometicort; Lemod; Depo M-Predrol; Medrol; Medrol acetate; Mepred; Methyl prednisolone acetate; Methylprednisolone 21-acetate; Methylprednisolone acetate; NSC 48985;

IUPAC/Chemical Name: 2-((6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

InChi Key: PLBHSZGDDKCEHR-LFYFAGGJSA-N

InChi Code: InChI=1S/C24H32O6/c1-13-9-16-17-6-8-24(29,20(28)12-30-14(2)25)23(17,4)11-19(27)21(16)22(3)7-5-15(26)10-18(13)22/h5,7,10,13,16-17,19,21,27,29H,6,8-9,11-12H2,1-4H3/t13-,16-,17-,19-,21+,22-,23-,24-/m0/s1

SMILES Code: CC(OCC([C@@]1(O)CC[C@@]2([H])[C@]3([H])C[C@H](C)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)=O)=O)=O

Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 416.50728 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Maman E, Yehuda C, Pritsch T, Morag G, Brosh T, Sharfman Z, Dolkart O.
Detrimental Effect of Repeated and Single Subacromial Corticosteroid Injections
on the Intact and Injured Rotator Cuff: A Biomechanical and Imaging Study in
Rats. Am J Sports Med. 2015 Jul 27. pii: 0363546515591266. [Epub ahead of print]
PubMed PMID: 26216105.

2: Rice DA, McNair PJ, Lewis GN, Dalbeth N. The effects of joint aspiration and
intra-articular corticosteroid injection on flexion reflex excitability,
quadriceps strength and pain in individuals with knee synovitis: a prospective
observational study. Arthritis Res Ther. 2015 Jul 28;17:191. doi:
10.1186/s13075-015-0711-5. PubMed PMID: 26215105; PubMed Central PMCID:
PMC4517546.