WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 315225
CAS#: 98651-66-2
Description: Ulobetasol (or halobetasol) is a corticosteroid used to treat psoriasis. It is a group I corticosteroid under the US classification, the most potent class of such drugs. Halobetasol propionate is usually supplied as a 0.05% topical cream. (Source: http://en.wikipedia.org/wiki/Halobetasol_propionate)
MedKoo Cat#: 315225
Name: Halobetasol propionate
CAS#: 98651-66-2
Chemical Formula: C22H27ClF2O4
Exact Mass: 428.15659
Molecular Weight: 428.9
Elemental Analysis: C, 61.61; H, 6.35; Cl, 8.27; F, 8.86; O, 14.92
Halobetasol propionate is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: Halobetasol; Ulobetasol
IUPAC/Chemical Name: (6α,11β,16β)-21-chloro-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
InChi Key: LEHFPXVYPMWYQD-XHIJKXOTSA-N
InChi Code: InChI=1S/C22H27ClF2O4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1
SMILES Code: C[C@@]12[C@](C(CCl)=O)(O)[C@@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
The following data is based on the product molecular weight 428.9 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Rivera AM, Hsu S. Topical halobetasol propionate in the treatment of plaque psoriasis: a review. Am J Clin Dermatol. 2005;6(5):311-6. Review. PubMed PMID: 16252930.