Fluorometholone acetate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 300140

CAS#: 426-13-1

Description: Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.

Chemical Structure

Fluorometholone acetate
CAS# 426-13-1

Theoretical Analysis

MedKoo Cat#: 300140
Name: Fluorometholone acetate
CAS#: 426-13-1
Chemical Formula: C24H31FO5
Exact Mass: 418.21
Molecular Weight: 418.5
Elemental Analysis: C, 68.88; H, 7.47; F, 4.54; O, 19.12

Size Price Shipping out time Quantity
25mg USD 150 2 Weeks
50mg USD 250 2 Weeks
200mg USD 450 2 Weeks
1g USD 850 2 Weeks
2g USD 1450 2 Weeks
5g USD 2250 2 Weeks
20g USD 4950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-28. Prices are subject to change without notice.

Fluorometholone acetate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: brand names FML (Allergan) and Flarex (Alcon). Oxylone acetate Fluorometholone 17acetate UNII9I50C3I3OK NSC 47438.

IUPAC/Chemical Name: (6S,9R,17R)-17-acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl acetate


InChi Code: InChI=1S/C24H31FO5/c1-13-10-19-17-7-9-23(14(2)26,30-15(3)27)22(17,5)12-20(29)24(19,25)21(4)8-6-16(28)11-18(13)21/h6,8,11,13,17,19-20,29H,7,9-10,12H2,1-5H3/t13-,17?,19?,20?,21?,22?,23-,24-/m0/s1

SMILES Code: CC(O[C@]1(C(C)=O)CCC2C3C[C@H](C)C4=CC(C=CC4(C)[C@@]3(F)C(O)CC12C)=O)=O

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO.

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 418.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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5: Borazan M, Karalezli A, Akova YA, Akman A, Kiyici H, Erbek SS. Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial. Acta Ophthalmol. 2009 Aug;87(5):549-54. Epub 2008 Jul 9. PubMed PMID: 18631332.

6: Bernauer W, Thiel MA, Rentsch KM. Phosphate concentration in ophthalmic corticoid preparations. Graefes Arch Clin Exp Ophthalmol. 2008 Jul;246(7):975-8. Epub 2008 Mar 21. PubMed PMID: 18357463.

7: Ramos-Esteban JC, Jeng BH. Posttraumatic Stenotrophomonas maltophilia infectious scleritis. Cornea. 2008 Feb;27(2):232-5. PubMed PMID: 18216585.

8: Szabó V, Borgulya G, Filkorn T, Majnik J, Bányász I, Nagy ZZ. The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy. Mol Vis. 2007 Apr 27;13:659-66. PubMed PMID: 17563720; PubMed Central PMCID: PMC2765477.

9: Rodrigues EB, Maia M, Meyer CH, Penha FM, Dib E, Farah ME. Vital dyes for chromovitrectomy. Curr Opin Ophthalmol. 2007 May;18(3):179-87. Review. PubMed PMID: 17435423.

10: Hata Y, Enaida H, Sassa Y, Ueno A, Miura M, Hisatomi T, Goto Y, Ishibashi T. Preclinical investigation of fluorometholone acetate as a potential new adjuvant during vitreous surgery. Graefes Arch Clin Exp Ophthalmol. 2007 Jul;245(7):1019-25. Epub 2006 Dec 21. PubMed PMID: 17186258.