WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 300140
CAS#: 426-13-1
Description: Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
MedKoo Cat#: 300140
Name: Fluorometholone acetate
CAS#: 426-13-1
Chemical Formula: C24H31FO5
Exact Mass: 418.21
Molecular Weight: 418.5
Elemental Analysis: C, 68.88; H, 7.47; F, 4.54; O, 19.12
Synonym: brand names FML (Allergan) and Flarex (Alcon). Oxylone acetate Fluorometholone 17acetate UNII9I50C3I3OK NSC 47438.
IUPAC/Chemical Name: (6S,9R,17R)-17-acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl acetate
InChi Key: YRFXGQHBPBMFHW-QVVVBGRGSA-N
InChi Code: InChI=1S/C24H31FO5/c1-13-10-19-17-7-9-23(14(2)26,30-15(3)27)22(17,5)12-20(29)24(19,25)21(4)8-6-16(28)11-18(13)21/h6,8,11,13,17,19-20,29H,7,9-10,12H2,1-5H3/t13-,17?,19?,20?,21?,22?,23-,24-/m0/s1
SMILES Code: CC(O[C@]1(C(C)=O)CCC2C3C[C@H](C)C4=CC(C=CC4(C)[C@@]3(F)C(O)CC12C)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO.
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 418.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Sohn S, Hur W, Choi YR, Chung YS, Ki CS, Kee C. Little evidence for association of the glaucoma gene MYOC with open-angle glaucoma. Br J Ophthalmol. 2010 May;94(5):639-42. PubMed PMID: 20447966.
2: Dib E, Rodrigues EB, Maia M, Meyer CH, Penha FM, Furlani Bde A, Costa Ede P, Farah ME. [Vital dyes in chromovitrectomy]. Arq Bras Oftalmol. 2009 Nov-Dec;72(6):845-50. Review. Portuguese. PubMed PMID: 20098913.
3: Erdurmus M, Cohen EJ, Yildiz EH, Hammersmith KM, Laibson PR, Varssano D, Rapuano CJ. Steroid-induced intraocular pressure elevation or glaucoma after penetrating keratoplasty in patients with keratoconus or Fuchs dystrophy. Cornea. 2009 Aug;28(7):759-64. PubMed PMID: 19574912.
4: Shao B, Cui X, Yang Y, Zhang J, Wu Y. Validation of a solid-phase extraction and ultra-performance liquid chromatographic tandem mass spectrometric method for the detection of 16 glucocorticoids in pig tissues. J AOAC Int. 2009 Mar-Apr;92(2):604-11. PubMed PMID: 19485221.
5: Borazan M, Karalezli A, Akova YA, Akman A, Kiyici H, Erbek SS. Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial. Acta Ophthalmol. 2009 Aug;87(5):549-54. Epub 2008 Jul 9. PubMed PMID: 18631332.
6: Bernauer W, Thiel MA, Rentsch KM. Phosphate concentration in ophthalmic corticoid preparations. Graefes Arch Clin Exp Ophthalmol. 2008 Jul;246(7):975-8. Epub 2008 Mar 21. PubMed PMID: 18357463.
7: Ramos-Esteban JC, Jeng BH. Posttraumatic Stenotrophomonas maltophilia infectious scleritis. Cornea. 2008 Feb;27(2):232-5. PubMed PMID: 18216585.
8: Szabó V, Borgulya G, Filkorn T, Majnik J, Bányász I, Nagy ZZ. The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy. Mol Vis. 2007 Apr 27;13:659-66. PubMed PMID: 17563720; PubMed Central PMCID: PMC2765477.
9: Rodrigues EB, Maia M, Meyer CH, Penha FM, Dib E, Farah ME. Vital dyes for chromovitrectomy. Curr Opin Ophthalmol. 2007 May;18(3):179-87. Review. PubMed PMID: 17435423.
10: Hata Y, Enaida H, Sassa Y, Ueno A, Miura M, Hisatomi T, Goto Y, Ishibashi T. Preclinical investigation of fluorometholone acetate as a potential new adjuvant during vitreous surgery. Graefes Arch Clin Exp Ophthalmol. 2007 Jul;245(7):1019-25. Epub 2006 Dec 21. PubMed PMID: 17186258.
