Flumethasone
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MedKoo CAT#: 315221

CAS#: 2135-17-3

Description: Flumetasone, also known as RS 2177, is a corticosteroid for topical use. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.


Chemical Structure

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Flumethasone
CAS# 2135-17-3

Theoretical Analysis

MedKoo Cat#: 315221
Name: Flumethasone
CAS#: 2135-17-3
Chemical Formula: C22H28F2O5
Exact Mass: 410.19
Molecular Weight: 410.450
Elemental Analysis: C, 64.38; H, 6.88; F, 9.26; O, 19.49

Price and Availability

Size Price Availability Quantity
50mg USD 250 2 Weeks
100mg USD 400 2 Weeks
500mg USD 750 2 Weeks
1g USD 1150 2 Weeks
Bulk inquiry

Synonym: RS 2177; RS-2177; RS2177; NSC 54702; U-10,974; U-10974; Anaprime; Aniprime; Fluvet; Methagon; BRN 5645455; Flumethasone; Cortexilar; Flucort; Flucorticin;Locacorten; Locorten

IUPAC/Chemical Name: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

InChi Key: WXURHACBFYSXBI-GQKYHHCASA-N

InChi Code: InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1

SMILES Code: O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(CO)=O)(O)[C@H](C)C[C@@]4([H])[C@]3([H])C[C@H](F)C2=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhou Y, Zhou Y, Wang K, Li T, Yang M, Wang R, Chen Y, Cao M, Hu R. Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. Cancer Lett. 2020 Apr 1;474:94-105. doi: 10.1016/j.canlet.2020.01.010. Epub 2020 Jan 16. PMID: 31954771.


2: Sternbauer K, Luthman J, Jacobsson SO. Flumethasone-induced insulin resistance in calves. Zentralbl Veterinarmed A. 1998 Sep;45(6-7):441-3. doi: 10.1111/j.1439-0442.1998.tb00846.x. PMID: 9793474.


3: Flumethasone pivalate (Locorten). Anti-inflammatory, antipruritic. Clin Pharmacol Ther. 1970 Nov-Dec;11(6):927-9. doi: 10.1002/cpt1970116927. PMID: 5481576.


4: Finley AG, Gunther WW. Flumethasone pivalate ("locacorten"), a new topical corticosteroid. Med J Aust. 1965 Nov 6;2(19):787-90. doi: 10.5694/j.1326-5377.1965.tb19272.x. PMID: 5852207.


5: Panaretto BA, Wallace AL. The administration of flumethasone, by three different routes, its measurement in the plasma and some effects on wool growth in Merino wethers. Aust J Biol Sci. 1978 Dec;31(6):601-19. doi: 10.1071/bi9780601. PMID: 754682.


6: Blake RL. Flumethasone induction of liver tyrosine aminotransferase activity in inbred strains and obese mutant mice. Biochem Pharmacol. 1970 May;19(5):1803-15. doi: 10.1016/0006-2952(70)90174-7. PMID: 4398019.


7: Carr RD, Wieland RG. Adrenocortical suppression with topical flumethasone. Arch Dermatol. 1967 Sep;96(3):269-72. PMID: 6038752.


8: Hojyo T. Combination dermatological products: a comparison of betamethasone dipropionate/clotrimazole/gentamicin sulphate and flumethasone pivalate/clioquinol creams. J Int Med Res. 1987 Sep-Oct;15(5):255-63. doi: 10.1177/030006058701500501. PMID: 2960577.


9: Willi RA, Salgueiro-González N, Faltermann S, Hettich T, Fent K. Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos. Sci Total Environ. 2019 Jul 1;672:183-191. doi: 10.1016/j.scitotenv.2019.03.426. Epub 2019 Mar 28. PMID: 30954817.


10: Brambilla G, Buiarelli F, Cartoni GP, Coccioli F, Colamonici C, Fagiolo A, Giannini C, Neri B. Determination of flumethasone in calf urine and serum by liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001 May 5;755(1-2):265-78. doi: 10.1016/s0378-4347(01)00122-0. PMID: 11393713.


11: Reding J, Sahin A, Schlatter J, Naegeli H. Dexamethasone and flumethasone residues in milk of intramuscularly dosed cows. J Vet Pharmacol Ther. 1997 Jun;20(3):198-203. doi: 10.1111/j.1365-2885.1997.tb00095.x. PMID: 9185085.


12: A Sayed R, Mohamed AR, Hassan WS, Elmasry MS. Comparative study of novel green UV-spectrophotometric platforms for simultaneous rapid analysis of flumethasone pivalate and clioquinol in their combined formulation. Drug Dev Ind Pharm. 2021 Jun;47(6):867-877. doi: 10.1080/03639045.2021.1908341. Epub 2021 Jul 5. PMID: 34224277.


13: Lodge BA, Vincent A. Analysis of flumethasone pivalate formulations by high- performance liquid chromatography. J Chromatogr. 1984 Oct 5;301(2):477-80. doi: 10.1016/s0021-9673(01)89223-2. PMID: 6501501.


14: Abdel-Aleem EA, Hegazy MA, Sayed NW, Abdelkawy M, Abdelfatah RM. Novel spectrophotometric determination of flumethasone pivalate and clioquinol in their binary mixture and pharmaceutical formulation. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt B:707-13. doi: 10.1016/j.saa.2014.09.085. Epub 2014 Sep 30. PMID: 25448970.


15: Zhang D, Park JA, Kim SK, Cho SH, Jeong D, Cho SM, Yi H, Shim JH, Kim JS, Abd El-Aty AM, Shin HC. Simultaneous detection of flumethasone, dl- methylephedrine, and 2-hydroxy-4,6-dimethylpyrimidine in porcine muscle and pasteurized cow milk using liquid chromatography coupled with triple-quadrupole mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:8-16. doi: 10.1016/j.jchromb.2016.01.011. Epub 2016 Jan 12. PMID: 26797492.


16: List RJ, Flook EP, Tay HL. Tympanoplasty graft preparation using ear drops containing polyethylene glycol, flumethasone and clioquinol. J Laryngol Otol. 2011 Aug;125(8):853-5. doi: 10.1017/S0022215111001083. Epub 2011 May 31. PMID: 21729449.


17: Grater WC, Grover FW. Evolution of a topical corticosteroid (flumethasone pivalate) in allergic dermatoses. South Med J. 1967 Nov;60(11):1153-8. doi: 10.1097/00007611-196711000-00001. PMID: 4228807.


18: Herasym K, Bonaparte JP, Kilty S. A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis. Laryngoscope. 2016 Jun;126(6):1411-9. doi: 10.1002/lary.25761. Epub 2015 Nov 24. PMID: 26600419.


19: Swanson LV, Lind RE. Lactational response of dairy cows to oral administration of a synthetic glucocorticoid. J Dairy Sci. 1976 Apr;59(4):614-9. doi: 10.3168/jds.S0022-0302(76)84249-X. PMID: 1262575.


20: Park KH, Choi JH, Abd El-Aty AM, Cho SK, Park JH, Kwon KS, Park HR, Kim HS, Shin HC, Kim MR, Shim JH. Development of QuEChERS-based extraction and liquid chromatography-tandem mass spectrometry method for quantifying flumethasone residues in beef muscle. Meat Sci. 2012 Dec;92(4):749-53. doi: 10.1016/j.meatsci.2012.06.033. Epub 2012 Jun 29. PMID: 22819726.