Flumethasone
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 315221

CAS#: 2135-17-3

Description: Flumetasone, also known as RS 2177, is a corticosteroid for topical use. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.


Chemical Structure

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Flumethasone
CAS# 2135-17-3

Theoretical Analysis

MedKoo Cat#: 315221
Name: Flumethasone
CAS#: 2135-17-3
Chemical Formula: C22H28F2O5
Exact Mass: 410.19048
Molecular Weight: 410.45
Elemental Analysis: C, 64.38; H, 6.88; F, 9.26; O, 19.49

Size Price Shipping out time Quantity
100mg USD 210 2 Weeks
200mg USD 250 2 Weeks
500mg USD 550 2 Weeks
1g USD 650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-04. Prices are subject to change without notice.

Flumethasone, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: RS 2177; RS-2177; RS2177; NSC 54702; U-10,974; U-10974; Anaprime; Aniprime; Fluvet; Methagon; BRN 5645455; Flumethasone; Cortexilar; Flucort; Flucorticin;Locacorten; Locorten

IUPAC/Chemical Name: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

InChi Key: WXURHACBFYSXBI-GQKYHHCASA-N

InChi Code: InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1

SMILES Code: O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(CO)=O)(O)[C@H](C)C[C@@]4([H])[C@]3([H])C[C@H](F)C2=C1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO.

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Van Den Hauwe O, Schneider M, Sahin A, Van Peteghem CH, Naegeli H. Immunochemical screening and liquid chromatographic-tandem mass spectrometric confirmation of drug residues in edible tissues of calves injected with a therapeutic dose of the synthetic glucocorticoids dexamethasone and flumethasone. J Agric Food Chem. 2003 Jan 1;51(1):326-30. PubMed PMID: 12502428.

2: Brambilla G, Buiarelli F, Cartoni GP, Coccioli F, Colamonici C, Fagiolo A, Giannini C, Neri B. Determination of flumethasone in calf urine and serum by liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001 May 5;755(1-2):265-78. PubMed PMID: 11393713.

3: Sternbauer K, Luthman J, Jacobsson SO. Flumethasone-induced insulin resistance in calves. Zentralbl Veterinarmed A. 1998 Sep;45(6-7):441-3. PubMed PMID: 9793474.

4: Reding J, Sahin A, Schlatter J, Naegeli H. Dexamethasone and flumethasone residues in milk of intramuscularly dosed cows. J Vet Pharmacol Ther. 1997 Jun;20(3):198-203. PubMed PMID: 9185085.

5: Sustronck B, Deprez P, van Loon G, Coghe J, Muylle E. Efficacy of the combination sodium ceftiofur-flumethasone in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves. Zentralbl Veterinarmed A. 1997 May;44(3):179-87. PubMed PMID: 9197206.

6: Gu X, Meleka-Boules M, Chen CL. Micellar electrokinetic capillary chromatography combined with immunoaffinity chromatography for identification and determination of dexamethasone and flumethasone in equine urine. J Capillary Electrophor. 1996 Jan-Feb;3(1):43-9. PubMed PMID: 9384764.

7: Stanley SM, Wilhelmi BS, Rodgers JP, Bertschinger H. Immunoaffinity chromatography combined with gas chromatography-negative ion chemical ionisation mass spectrometry for the confirmation of flumethasone abuse in the equine. J Chromatogr. 1993 Apr 21;614(1):77-86. PubMed PMID: 8496289.

8: Karatzias H. [The effectiveness of cholecalciferol and flumethasone for the prevention of hypocalcemic parturient paresis in dairy cows]. Dtsch Tierarztl Wochenschr. 1992 Aug;99(8):326-7. German. PubMed PMID: 1330480.

9: Hojyo T. Combination dermatological products: a comparison of betamethasone dipropionate/clotrimazole/gentamicin sulphate and flumethasone pivalate/clioquinol creams. J Int Med Res. 1987 Sep-Oct;15(5):255-63. PubMed PMID: 2960577.

10: Mosca M, Zambruno G, Giannetti A. [Double-blind comparison of a betamethasone dipropionate-iodochloroxyquinoline combination and a flumethasone pivalate-iodochloroxyquinoline combination in the therapy of steroid-sensitive dermatoses with superinfection]. G Ital Dermatol Venereol. 1986 Jan-Feb;121(1):XI-XIV. Italian. PubMed PMID: 2939023.