Estrone
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MedKoo CAT#: 300149

CAS#: 53-16-7

Description: Estrone (E1, and also oestrone) is an estrogenic hormone secreted by the ovary as well as adipose tissue. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. Estrone is the only estrogen which is present in any quantity in post-menopausal women. (Source: http://en.wikipedia.org/wiki/Estrone).


Chemical Structure

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Estrone
CAS# 53-16-7

Theoretical Analysis

MedKoo Cat#: 300149
Name: Estrone
CAS#: 53-16-7
Chemical Formula: C18H22O2
Exact Mass: 270.16198
Molecular Weight: 270.37
Elemental Analysis: C, 79.96; H, 8.20; O, 11.84

Price and Availability

Size Price Availability Quantity
500.0mg USD 90.0 2 weeks
1.0g USD 150.0 2 weeks
2.0g USD 250.0 2 weeks
5.0g USD 450.0 2 weeks
10.0g USD 750.0 2 weeks
20.0g USD 1450.0 2 weeks
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Synonym: oestrone.

IUPAC/Chemical Name: (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one

InChi Key: DNXHEGUUPJUMQT-CBZIJGRNSA-N

InChi Code: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

SMILES Code: O=C1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@]12C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 270.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Remesar X, Fernández-López JA, Alemany M. Oleoyl-estrone. Med Res Rev. 2012 Nov;32(6):1263-91. doi: 10.1002/med.20240. Epub 2011 Feb 1. Review. PubMed PMID:   21287573.

Estrone

500.0mg / USD 90.0