WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 315241

CAS#: 50-27-1

Description: Estriol (also oestriol) is one of the three main estrogens produced by the human body. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School. Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol. Estriol may play a role in the development of breast cancer, but based on in vitro research does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. (Source:

Chemical Structure

CAS# 50-27-1

Theoretical Analysis

MedKoo Cat#: 315241
Name: Estriol
CAS#: 50-27-1
Chemical Formula: C18H24O3
Exact Mass: 288.17254
Molecular Weight: 288.38
Elemental Analysis: C, 74.97; H, 8.39; O, 16.64

Size Price Shipping out time Quantity
50mg USD 90 2 weeks
100mg USD 120 2 weeks
200mg USD 180 2 weeks
500mg USD 250 2 weeks
1g USD 350 2 weeks
2g USD 450 2 weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-28. Prices are subject to change without notice.

Estriol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: oestriol.

IUPAC/Chemical Name: (8R,9S,13S,14S,16R,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,16,17-triol


InChi Code: InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

SMILES Code: OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)[C@H](O)C[C@@]4([H])[C@]3([H])CCC2=C1

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO.

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 288.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Donders G, Bellen G, Neven P, Grob P, Prasauskas V, Buchholz S, Ortmann O. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis. 2015 Jul 30. [Epub ahead of print] PubMed PMID: 26223323.

2: Caruso S, Cianci S, Amore FF, Ventura B, Bambili E, Spadola S, Cianci A. Quality of life and sexual function of naturally postmenopausal women on an ultralow-concentration estriol vaginal gel. Menopause. 2015 Jun 15. [Epub ahead of print] PubMed PMID: 26079974.

3: Castellani D, Saldutto P, Galica V, Pace G, Biferi D, Paradiso Galatioto G, Vicentini C. Low-Dose Intravaginal Estriol and Pelvic Floor Rehabilitation in Post-Menopausal Stress Urinary Incontinence. Urol Int. 2015 May 30. [Epub ahead of print] PubMed PMID: 26043913.

4: Soghra K, Zohreh S, Kobra AK, Reza MM. Single measurement of salivary estriol as a predictor of preterm birth. Pak J Biol Sci. 2014 May;17(5):730-4. PubMed PMID: 26031009.

5: Tomi M, Eguchi H, Ozaki M, Tawara T, Nishimura S, Higuchi K, Maruyama T, Nishimura T, Nakashima E. Role of OAT4 in Uptake of Estriol Precursor 16α-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus. Endocrinology. 2015 Jul;156(7):2704-12. doi: 10.1210/en.2015-1130. Epub 2015 Apr 28. PubMed PMID: 25919187.

6: Durković J, Milenković T, Krone N, Parajes S, Mandić B. Low estriol levels in the maternal marker screen as a predictor of X-linked adrenal hypoplasia congenita: case report. Srp Arh Celok Lek. 2014 Nov-Dec;142(11-12):728-31. PubMed PMID: 25731006.

7: Liu ZH, Lu GN, Yin H, Dang Z. Do we underestimate the concentration of estriol in raw municipal wastewater? Environ Sci Pollut Res Int. 2015 Mar;22(6):4753-8. doi: 10.1007/s11356-014-3981-6. Epub 2014 Dec 24. PubMed PMID: 25537286.

8: Shirshev SV, Maslennikova IL, Nekrasova IV. [Effect of Escherichia coli secreted metabolites on functional activity of human neutrophils against the background of estriol effect]. Zh Mikrobiol Epidemiol Immunobiol. 2014 Sep-Oct;(5):65-70. Russian. PubMed PMID: 25536774.

9: Yamabe N, Kang KS, Lee W, Kim SN, Zhu BT. Estriol blunts postprandial blood glucose rise in male rats through regulating intestinal glucose transporters. Am J Physiol Endocrinol Metab. 2015 Mar 1;308(5):E370-9. doi: 10.1152/ajpendo.00209.2013. Epub 2014 Dec 16. PubMed PMID: 25516546; PubMed Central PMCID: PMC4346740.

10: Girgert R, Emons G, Gründker C. Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17β-estradiol. BMC Cancer. 2014 Dec 11;14:935. doi: 10.1186/1471-2407-14-935. PubMed PMID: 25496649; PubMed Central PMCID: PMC4364648.