Dexamethasone
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MedKoo CAT#: 315269

CAS#: 50-02-2 (free base)

Description: Dexamethasone is a type of steroid medication. It has anti-inflammatory and immunosuppressant effects. It is 25 times more potent than cortisol in its glucocorticoid effect, while having minimal mineralocorticoid effect. Dexamethasone is used for the treatment of many conditions including: rheumatologic problems, a number of skin diseases such as erythema multiforme, severe allergies, asthma, chronic obstructive lung disease, croup, and cerebral edema, in addition to other medications in tuberculosis and a number of other infectious diseases.


Chemical Structure

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Dexamethasone
CAS# 50-02-2 (free base)

Theoretical Analysis

MedKoo Cat#: 315269
Name: Dexamethasone
CAS#: 50-02-2 (free base)
Chemical Formula: C22H29FO5
Exact Mass: 392.1999
Molecular Weight: 392.46
Elemental Analysis: C, 67.33; H, 7.45; F, 4.84; O, 20.38

Price and Availability

Size Price Availability Quantity
1.0g USD 250.0 Same day
2.0g USD 450.0 Same day
5.0g USD 650.0 Same day
10.0g USD 950.0 Same day
20.0g USD 1450.0 Same day
50.0g USD 1950.0 Same day
100.0g USD 2950.0 Same day
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Related CAS #: 3936-02-5 (metasulfobenzoate sodium)   3800-84-8 (sodium succinate)   1177-87-3 (acetate)   150587-07-8 (beloxil)   132245-57-9 (cipecilate)   2265-64-7 (isonicotinate)   14899-36-6 (palmitate)   312-93-6 (phosphate)   2392-39-4 (sodium phosphate)  

Synonym: Decaject; Decaject L.A.; Decaject-L.A.; Decameth; Decaspray; Dexamethasone; Dexasone; Dexpak; .Hexadecadrol; Hexadrol.; Maxidex; Methylfluorprednisolone; Millicorten; Oradexon

IUPAC/Chemical Name: (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

InChi Key: UREBDLICKHMUKA-CXSFZGCWSA-N

InChi Code: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

SMILES Code: O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(CO)=O)(O)[C@H](C)C[C@@]4([H])[C@]3([H])CCC2=C1

Appearance: solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 392.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Warris LT, van den Heuvel-Eibrink MM, den Hoed MA, Aarsen FK, Pieters R, van den Akker EL. Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review. Pediatr Blood Cancer. 2014 Jul;61(7):1313-8. doi: 10.1002/pbc.24988. Epub 2014 Feb 16. Review. PubMed PMID: 24532490.

2: Keeney GE, Gray MP, Morrison AK, Levas MN, Kessler EA, Hill GD, Gorelick MH, Jackson JL. Dexamethasone for acute asthma exacerbations in children: a meta-analysis. Pediatrics. 2014 Mar;133(3):493-9. doi: 10.1542/peds.2013-2273. Epub 2014 Feb 10. Review. PubMed PMID: 24515516; PubMed Central PMCID: PMC3934336.

3: Choi S, Rodseth R, McCartney CJ. Effects of dexamethasone as a local anaesthetic adjuvant for brachial plexus block: a systematic review and meta-analysis of randomized trials. Br J Anaesth. 2014 Mar;112(3):427-39. doi: 10.1093/bja/aet417. Epub 2014 Jan 10. Review. PubMed PMID: 24413428.

4: Urbańska J, Karewicz A, Nowakowska M. Polymeric delivery systems for dexamethasone. Life Sci. 2014 Feb 6;96(1-2):1-6. doi: 10.1016/j.lfs.2013.12.020. Epub 2013 Dec 25. Review. PubMed PMID: 24373835.

5: Redman E, Powell C. Question 1: Prednisolone or dexamethasone for acute exacerbations of asthma: do they have similar efficacy in the management of exacerbations of childhood asthma? Arch Dis Child. 2013 Nov;98(11):916-9. doi: 10.1136/archdischild-2013-304937. Review. PubMed PMID: 24123403.

6: Kutz JW Jr, Roland PS, Lee KH. Ciprofloxacin 0.3% + dexamethasone 0.1% for the treatment for otitis media. Expert Opin Pharmacother. 2013 Dec;14(17):2399-405. doi: 10.1517/14656566.2013.844789. Epub 2013 Oct 7. Review. PubMed PMID: 24093464.

7: Ohashi K, Yokoyama A, Kagoo T, Hosoda T, Yamamoto R, Yoneda M, Kudo M, Boku S, Ueno H, Yano T. [Rapid improvement of fluid retention with lenalidomide plus low-dose dexamethasone for POEMS syndrome relapsed after autologous peripheral blood stem cell transplantation]. Rinsho Ketsueki. 2013 Jul;54(7):670-4. Review. Japanese. PubMed PMID: 23912352.

8: Bernardo WM, Aires FT. Efficacy of dexamethasone in the prophylaxis of nausea and vomiting during the postoperative period of laparoscopic cholecystectomy. Rev Assoc Med Bras. 2013 Jul-Aug;59(4):387-91. doi: 10.1016/j.ramb.2013.06.008. Epub 2013 Jul 16. Review. English, Portuguese. PubMed PMID: 23866937.

9: Sekiguchi Y, Asahina T, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Komatsu N, Noguchi M. A case of extramedullary plasmablastic plasmacytoma successfully treated using a combination of thalidomide and dexamethasone and a review of the medical literature. J Clin Exp Hematop. 2013;53(1):21-8. Review. PubMed PMID: 23801130.

10: Ueda S, Kubo M, Matsuura N, Matsunaga H, Kataoka S, Maeda T, Inui Y, Kawata S, Kanakura Y. Stringent complete remission of primary plasma cell leukemia with reduced-dose bortezomib, lenalidomide and dexamethasone: a case report and review of the literature. Intern Med. 2013;52(11):1235-8. Review. PubMed PMID: 23728562.