WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 315291
CAS#: 25122-46-7 (propionate)
Description: Clobetasol propionate is a corticosteroid used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules).
MedKoo Cat#: 315291
Name: Clobetasol Propionate
CAS#: 25122-46-7 (propionate)
Chemical Formula: C25H32ClFO5
Exact Mass: 466.19223
Molecular Weight: 466.96998
Elemental Analysis: C, 64.30; H, 6.91; Cl, 7.59; F, 4.07; O, 17.13
Related CAS #: 25122-46-7 (propionate) 25122-41-2 (free base)
Synonym: Clobex Cosvate (India) Temovate (US)Olux Tenovate Dermovate Dermatovate Butavate Movate Novate. 17(2chloroacetyl) 9fluoro11hydroxy101316trimethyl 3oxo6781112141516octahydrocyclopentaaphenanthren17yl propanoate
IUPAC/Chemical Name: (8S,9R,10S,11S,13R,14S,16S,17R)-13-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,16,17-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
InChi Key: FKWXHUWJFNMNSE-NQNWYGNOSA-N
InChi Code: InChI=1S/C25H32ClFO5/c1-5-21(31)32-23(4)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)25(17,27)19(29)12-24(18,23)20(30)13-26/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23+,24-,25-/m0/s1
SMILES Code: CCC(O[C@]1(C)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C(CCl)=O)=O)=O
Appearance: White to off-white crystalline powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO.
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 466.96998 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nakayama K, Sato K, Shibano T, Isobe T, Suzuki G, Kitamura SI. Occurrence of glucocorticoids discharged from a sewage treatment plant in Japan and the effects of clobetasol propionate exposure on the immune responses of common carp (Cyprinus carpio) to bacterial infection. Environ Toxicol Chem. 2015 Jun 30. doi: 10.1002/etc.3136. [Epub ahead of print] PubMed PMID: 26126539.
2: Corazza M, Borghi A, Minghetti S, Toni G, Virgili A. Clobetasol propionate vs. mometasone furoate in 1-year proactive maintenance therapy of vulvar lichen sclerosus: results from a comparative trial. J Eur Acad Dermatol Venereol. 2015 Apr 22. doi: 10.1111/jdv.13166. [Epub ahead of print] PubMed PMID: 25904498.
3: Purusothaman R, Rajesh P, Ramasamy P. Growth and characterization of organic NLO material: clobetasol propionate. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jun 15;145:235-8. doi: 10.1016/j.saa.2015.03.014. Epub 2015 Mar 10. PubMed PMID: 25791879.
4: Wiser TH, Meckfessel MH, Winkelman W. The use of a reliable, ubiquitous, inexpensive, and user-friendly tablet-based system to track target lesion improvements in subjects with plaque psoriasis treated with clobetasol propionate 0.05% spray. J Drugs Dermatol. 2015 Mar;14(3):236-43. PubMed PMID: 25738845.
5: Brødsgaard A, Nielsen T, Mølgaard U, Pryds O, Pedersen P. Treating infants for umbilical granuloma with topical clobetasol propionate cream. Acta Paediatr. 2015 Feb;104(2):e49-50. doi: 10.1111/apa.12867. PubMed PMID: 25399633.
6: Aydin M, Orman A, Deveci U, Taskin E. Topical clobetasol propionate may not be safe for treating umbilical granuloma in infants. Acta Paediatr. 2015 Feb;104(2):e49. doi: 10.1111/apa.12849. Epub 2014 Dec 10. PubMed PMID: 25366299.
7: Brødsgaard A, Nielsen T, Mølgaard U, Pryds O, Pedersen P. Treating umbilical granuloma with topical clobetasol propionate cream at home is as effective as treating it with topical silver nitrate in the clinic. Acta Paediatr. 2015 Feb;104(2):174-7. doi: 10.1111/apa.12824. Epub 2014 Nov 4. PubMed PMID: 25297721.
8: Haddican M, Linkner RV, Singer G, Jim SC, Gagliotti M, Goldenberg G. Retapamulin 1% Ointment and Clobetasol Propionate 0.05% Foam is More Efficacious than Vehicle Ointment and Clobetasol 0.05% Propionate Foam in the Treatment of Hand/Foot Dermatitis: A Single Center, Randomized, Double-blind Study. J Clin Aesthet Dermatol. 2014 Jul;7(7):32-6. PubMed PMID: 25053981; PubMed Central PMCID: PMC4106355.
9: Patel HK, Barot BS, Parejiya PB, Shelat PK, Shukla A. Topical delivery of clobetasol propionate loaded microemulsion based gel for effective treatment of vitiligo--part II: rheological characterization and in vivo assessment through dermatopharmacokinetic and pilot clinical studies. Colloids Surf B Biointerfaces. 2014 Jul 1;119:145-53. doi: 10.1016/j.colsurfb.2014.02.005. Epub 2014 Mar 29. PubMed PMID: 24767976.
10: Funaro D, Lovett A, Leroux N, Powell J. A double-blind, randomized prospective study evaluating topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in patients with vulvar lichen sclerosus. J Am Acad Dermatol. 2014 Jul;71(1):84-91. doi: 10.1016/j.jaad.2014.02.019. Epub 2014 Apr 3. PubMed PMID: 24704090.
