WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 314216

CAS#: 22316-47-8

Description: Clobazam is a benzodiazepine derivative. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. Clobazam is discontinued.

Chemical Structure

CAS# 22316-47-8

Theoretical Analysis

MedKoo Cat#: 314216
Name: Clobazam
CAS#: 22316-47-8
Chemical Formula: C16H13ClN2O2
Exact Mass: 300.06656
Molecular Weight: 300.74
Elemental Analysis: C, 63.90; H, 4.36; Cl, 11.79; N, 9.31; O, 10.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Frisium; Urbanol; Onfi; H-4723; HR 376; HSDB 8343; LM 2717; LM-2717; Noiafren; NSC 336279; RU-4723; Urbadan; Urbanil; Urbanyl.

IUPAC/Chemical Name: 7-Chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione


InChi Code: InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3

SMILES Code: O=C(C1)N(C)C2=CC=C(Cl)C=C2N(C3=CC=CC=C3)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 300.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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1: Purcarin G, Ng YT. Experience in the use of clobazam in the treatment of Lennox-Gastaut syndrome. Ther Adv Neurol Disord. 2014 May;7(3):169-176. Review. PubMed PMID: 24790647; PubMed Central PMCID: PMC3994921.

2: Cramer JA, Sapin C, François C. Indirect comparison of clobazam and other therapies for Lennox-Gastaut syndrome. Acta Neurol Scand. 2013 Aug;128(2):91-9. doi: 10.1111/ane.12086. Epub 2013 Feb 15. Review. PubMed PMID: 23410109.

3: de Leon J, Spina E, Diaz FJ. Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies. Ther Drug Monit. 2013 Feb;35(1):30-47. doi: 10.1097/FTD.0b013e31827ada88. Review. PubMed PMID: 23318278; PubMed Central PMCID: PMC3546316.

4: Owen RT. The use of clobazam as an adjunctive treatment for Lennox-Gastaut syndrome. Drugs Today (Barc). 2012 Nov;48(11):697-703. doi: 10.1358/dot.2012.48.11.1879453. Review. PubMed PMID: 23170305.

5: Wheless JW, Phelps SJ. Clobazam: a newly approved but well-established drug for the treatment of intractable epilepsy syndromes. J Child Neurol. 2013 Feb;28(2):219-29. doi: 10.1177/0883073812463609. Epub 2012 Oct 30. Review. PubMed PMID: 23112237.

6: Yang LP, Scott LJ. Clobazam : in patients with Lennox-Gastaut syndrome. CNS Drugs. 2012 Nov;26(11):983-91. doi: 10.1007/s40263-012-0007-0. Review. PubMed PMID: 23034582.

7: Seif-Eddeine H, Ng YT. Clobazam for patients with Lennox-Gastaut syndrome and epilepsy. Expert Rev Neurother. 2012 Apr;12(4):385-93. doi: 10.1586/ern.12.14. Review. PubMed PMID: 22449211.