Cefsulodine sodium hydrate | CAS# 52152-93-9 (salt)

Cefsulodine sodium hydrate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 315129

CAS#: 1426397-23-0 (sodium hydrate)

Description: Cefsulodin sodium is a narrow-spectrum cephalosporin with marked in vitro activity against clinical isolates of Pseudomonas aeruginosa.

Chemical Structure

Cefsulodine sodium hydrate

CAS# 1426397-23-0 (sodium hydrate)

Instruction

Theoretical Analysis

MedKoo Cat#: 315129
Name: Cefsulodine sodium hydrate
CAS#: 1426397-23-0 (sodium hydrate)
Chemical Formula: C22H21N4NaO9S2
Exact Mass: 0.00
Molecular Weight: 572.539
Elemental Analysis: C, 46.15; H, 3.70; N, 9.79; Na, 4.02; O, 25.15; S, 11.20

Price and Availability

Size	Price	Availability
200mg	USD 250	2 Weeks
500mg	USD 450	2 Weeks
1g	USD 750	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 62587-73-9 (free acid) 52152-93-9 (sodium) 1426397-23-0 (sodium hydrate)

Synonym: CGP 7174E; CGP-7174E; CGP7174E; CGP-7174/E; Abbott 46811; Abbott-468 11; Abbott-46811; Cefomonil; Cefsulodine sodium hydrate; Pseudocef; Pseudomonil; Pyocefal;

IUPAC/Chemical Name: sodium (6R,7R)-3-((4-carbamoylpyridin-1-ium-1-yl)methyl)-8-oxo-7-((R)-2-phenyl-2-sulfonatoacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrate

InChi Key: XTRRFIYXAPRYES-NLFZDHTNSA-M

InChi Code: InChI=1S/C22H20N4O8S2.Na.H2O/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);;1H2/q;+1;/p-1/t15-,17-,21-;;/m1../s1

SMILES Code: O=C(C(N12)=C(C[N+]3=CC=C(C(N)=O)C=C3)CS[C@]2([H])[C@H](NC([C@@H](C4=CC=CC=C4)S(=O)([O-])=O)=O)C1=O)[O-].[H]O[H].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 572.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Zhang ZY. Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis. ACS Med Chem Lett. 2015 Nov 3;6(12):1231-5. doi: 10.1021/acsmedchemlett.5b00373. PMID: 26713110; PMCID: PMC4677373.

2: Tan LK, Ooi PT, Carniel E, Thong KL. Evaluation of a modified Cefsulodin- Irgasan-Novobiocin agar for isolation of Yersinia spp. PLoS One. 2014 Aug 29;9(8):e106329. doi: 10.1371/journal.pone.0106329. PMID: 25170941; PMCID: PMC4149559.

3: Sarkar SK, Dutta M, Kumar A, Mallik D, Ghosh AS. Sub-inhibitory cefsulodin sensitization of E. coli to β-lactams is mediated by PBP1b inhibition. PLoS One. 2012;7(11):e48598. doi: 10.1371/journal.pone.0048598. Epub 2012 Nov 6. PMID: 23139798; PMCID: PMC3490869.

4: González M, Gude MJ, Seral C, Abad MP, Algarate S, Castillo FJ. Comparación de dos métodos para la recuperación de Aeromonas spp. de heces a partir de agar CIN (Cefsulodina-Irgasan-Novobiocina) [Comparasion of two methods for recovery of Aeromonas spp. in feces from agar CIN (Cefsulodin-Irgasan-Novobiocin)]. Rev Esp Quimioter. 2010 Dec;23(4):217-8. Spanish. PMID: 21191564.

5: Endo R, Yamane N, Tamayose MH, Uchibori KK, Nakasone I. [A simple disk diffusion test to identify beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae--application of cephalexin, cefsulodin and cefaclor disks]. Rinsho Byori. 2010 Oct;58(10):963-71. Japanese. PMID: 21077285.

6: Logue CM, Sherwood JS, Doetkott C. Growth studies of plasmid bearing and plasmid cured Yersinia enterocolitica GER O:3 in the presence of cefsulodin, irgasan and novobiocin at 25 and 37 degrees C. J Appl Microbiol. 2006 Jun;100(6):1299-306. doi: 10.1111/j.1365-2672.2006.02861.x. PMID: 16696677.

7: Tsai TH, Cheng FC, Chen YF, Chen CF. On-line microdialysis coupled with microbore liquid chromatography with ultraviolet detection for continuous monitoring of free cefsulodin in rat blood. J Chromatogr A. 2001 Apr 20;914(1-2):83-7. doi: 10.1016/s0021-9673(00)01205-x. PMID: 11358235.

8: Hornitzky MA, Bettelheim KA, Djordjevic SP. The detection of Shiga toxin- producing Escherichia coli in diagnostic bovine faecal samples using vancomycin- cefixime-cefsulodin blood agar and PCR. FEMS Microbiol Lett. 2001 Apr 20;198(1):17-22. doi: 10.1111/j.1574-6968.2001.tb10613.x. PMID: 11325548.

9: Lehmacher A, Meier H, Aleksic S, Bockemühl J. Detection of hemolysin variants of Shiga toxin-producing Escherichia coli by PCR and culture on vancomycin- cefixime-cefsulodin blood agar. Appl Environ Microbiol. 1998 Jul;64(7):2449-53. doi: 10.1128/AEM.64.7.2449-2453.1998. PMID: 9647814; PMCID: PMC106410.

10: Smith A, Baker M. Cefsulodin chocolate blood agar: a selective medium for the recovery of Haemophilus influenzae from the respiratory secretions of patients with cystic fibrosis. J Med Microbiol. 1997 Oct;46(10):883-5. doi: 10.1099/00222615-46-10-883. PMID: 9364146.

11: Nerli B, Farruggia B, Picó G. A comparative study of the binding characteristics of ceftriaxone, cefoperazone and cefsulodin to human serum albumin. Biochem Mol Biol Int. 1996 Nov;40(4):823-31. doi: 10.1080/15216549600201433. PMID: 8950041.

12: Alonso JL, Amoros I, Alonso MA. Differential susceptibility of aeromonads and coliforms to cefsulodin. Appl Environ Microbiol. 1996 Oct;62(10):3914. doi: 10.1128/AEM.62.10.3914-3914.1996. Erratum for: Appl Environ Microbiol. 62:1885. PMID: 16535434; PMCID: PMC1388972.

13: Alonso JL, Amoros I, Alonso MA. Differential susceptibility of aeromonads and coliforms to cefsulodin. Appl Environ Microbiol. 1996 Jun;62(6):1885-8. doi: 10.1128/AEM.62.6.1885-1888.1996. Erratum in: Appl Environ Microbiol 1996 Oct;62(10):3914. PMID: 8787387; PMCID: PMC167967.

14: Ishibashi K, Yamaguchi O, Shiraiwa Y, Ogihara M, Shigeta S. Combination therapy of Pseudomonas aeruginosa pyelonephritis in neutropenic mice with human antilipopolysaccharide monoclonal antibody and cefsulodin. J Urol. 1996 Jun;155(6):2094-7. PMID: 8618343.

15: Murillo JA, Lemus JM, García LF. Simultaneous determination of the binary mixtures of cefsulodin and clavulanic acid by using first-derivative spectrophotometry. J Pharm Biomed Anal. 1995 May;13(6):769-76. doi: 10.1016/0731-7085(95)01281-o. PMID: 7669831.

16: Reina J, Serra A, Borrell N. Eficacia del medio cefsulodina-irgasan- novobiocina agar en el aislamiento de Aeromonas mesófilas en las heces [Efficacy of cefsulodin -irgasan-novobiocin agar media in the isolation of Aeromonas mesophiles from feces]. Enferm Infecc Microbiol Clin. 1993 Feb;11(2):114-6. Spanish. PMID: 8481436.

17: Gorski RJ, Plasz AC, Elrod L Jr, Yoder J, White LB. Determination of cefsulodin, cefmenoxime, and cefadroxil as residues on surfaces. Pharm Res. 1991 Dec;8(12):1525-7. doi: 10.1023/a:1015850517994. PMID: 1808618.

18: Baltch AL, Bassey C, Hammer MC, Smith RP, Conroy JV, Michelsen PB. Synergy with cefsulodin or piperacillin and three aminoglycosides or aztreonam against aminoglycoside resistant strains of Pseudomonas aeruginosa. J Antimicrob Chemother. 1991 Jun;27(6):801-8. doi: 10.1093/jac/27.6.801. PMID: 1938686.

19: Jacoby GH, Young KD. Cell cycle-independent lysis of Escherichia coli by cefsulodin, an inhibitor of penicillin-binding proteins 1a and 1b. J Bacteriol. 1991 Jan;173(1):1-5. doi: 10.1128/jb.173.1.1-5.1991. PMID: 1987110; PMCID: PMC207148.

20: Qadri SM, Billington O, Cunha BA. In vitro activity of cefsulodin against multi-resistant isolates of Pseudomonas aeruginosa. Drugs Exp Clin Res. 1991;17(4):213-6. PMID: 1794295.

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Cefsulodine sodium hydrate featured