Betamethasone
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MedKoo CAT#: 300150

CAS#: 378-44-9

Description: Betamethasone is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments including allergic reactions to poison ivy and similar plants.


Chemical Structure

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Betamethasone
CAS# 378-44-9

Theoretical Analysis

MedKoo Cat#: 300150
Name: Betamethasone
CAS#: 378-44-9
Chemical Formula: C22H29FO5
Exact Mass: 392.1999
Molecular Weight: 392.46
Elemental Analysis: C, 67.33; H, 7.45; F, 4.84; O, 20.38

Price and Availability

Size Price Availability Quantity
10.0mg USD 55.0 2 weeks
25.0mg USD 60.0 2 weeks
50.0mg USD 70.0 2 weeks
100.0mg USD 80.0 2 weeks
200.0mg USD 90.0 2 weeks
500.0mg USD 120.0 2 weeks
1.0g USD 150.0 2 weeks
2.0g USD 250.0 2 weeks
5.0g USD 450.0 2 weeks
10.0g USD 650.0 2 weeks
20.0g USD 1150.0 2 weeks
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Synonym: (8S9R10S11S13S14S16S17R)9fluoro 1117dihydroxy17(2hydroxyacetyl)101316trimethyl 67891011121314151617dodecahydro 3Hcyclopentaaphenanthren3one.

IUPAC/Chemical Name: (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one.

SMILES Code: O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(CO)=O)(O)[C@@H](C)C[C@@]4([H])[C@]3([H])CCC2=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 392.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Ma L, Yang Q, Yang H, Wang G, Zheng M, Hao F, Gu J, Sun Q, Cui P, Ge M, Li R, Gao T, Facy P, Kurvits M, Xu Z, Xu J. Calcipotriol plus betamethasone dipropionate gel compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized, controlled trial investigating efficacy and safety in a Chinese population. Int J Dermatol. 2015 Jun 20. doi: 10.1111/ijd.12788. [Epub ahead of print] PubMed PMID: 26094549.

2: Giraddi GB, Siddaraju A, Kumar A, Jain T. Comparison Between Betamethasone and Sodium Hyaluronate Combination with Betamethasone Alone After Arthrocentesis in the Treatment of Internal Derangement of TMJ-Using Single Puncture Technique: A Preliminary Study. J Maxillofac Oral Surg. 2015 Jun;14(2):403-9. doi: 10.1007/s12663-014-0626-8. Epub 2014 May 7. PubMed PMID: 26028866; PubMed Central PMCID: PMC4444658.

3: Cohen G, Natsheh H, Sunny Y, Bawiec CR, Touitou E, Lerman MA, Lazarovici P, Lewin PA. Enhanced Therapeutic Anti-inflammatory Effect of Betamethasone on Topical Administration with Low-Frequency, Low-Intensity (20 kHz, 100 mW/cm(2)) Ultrasound Exposure on Carrageenan-Induced Arthritis in a Mouse Model. Ultrasound Med Biol. 2015 May 20. pii: S0301-5629(15)00308-7. doi: 10.1016/j.ultrasmedbio.2015.04.009. [Epub ahead of print] PubMed PMID: 26003010.

4: Wong W, Maher DP, Iyayi D, Lopez R, Shamloo B, Rosner H, Yumul R. Increased dose of betamethasone for transforaminal epidural steroid injections is not associated with superior pain outcomes at 4 weeks. Pain Physician. 2015 May-Jun;18(3):E355-61. PubMed PMID: 26000682.

5: Sifianou P, Thanou V, Karga H. Metabolic and hormonal effects of antenatal betamethasone after 35 weeks of gestation. J Pediatr Pharmacol Ther. 2015 Mar-Apr;20(2):138-43. doi: 10.5863/1551-6776-20.2.138. PubMed PMID: 25964731; PubMed Central PMCID: PMC4418681.

6: França MS, Moron AF, Araujo Júnior E, Avedissian M, Pares DB, Nardozza LM, Jaqueta CB, Mello LE. Neonatal neuronal apoptosis after betamethasone administration in pregnant Wistar rats. J Matern Fetal Neonatal Med. 2015 Apr 29:1-5. [Epub ahead of print] PubMed PMID: 25923240.

7: Pohl O, Homery MC, Lemaux F, Patat A, Chollet A. Pharmacokinetic interactions of OBE001 and betamethasone in healthy female volunteers. J Clin Pharm Ther. 2015 Jun;40(3):328-32. doi: 10.1111/jcpt.12258. Epub 2015 Feb 26. PubMed PMID: 25899007.

8: Maccari F. Improvement of inflammatory dermatoses severity and quality of life in patients treated with a betamethasone valerate plaster (LIBERE study). J Dermatolog Treat. 2015 Jun 15:1-5. [Epub ahead of print] PubMed PMID: 25898980.

9: Byrne J, Velasco-Torrijos T, Reinhardt R. An RP-HPLC Method for the Stability-Indicating Analysis of Impurities of Both Fusidic Acid and Betamethasone-17-Valerate in a Semi-Solid Pharmaceutical Dosage Form. J Chromatogr Sci. 2015 Apr 19. pii: bmv045. [Epub ahead of print] PubMed PMID: 25896658.

10: Pascual R, Valencia M, Bustamante C. Antenatal betamethasone produces protracted changes in anxiety-like behaviors and in the expression of microtubule-associated protein 2, brain-derived neurotrophic factor and the tyrosine kinase B receptor in the rat cerebellar cortex. Int J Dev Neurosci. 2015 Jun;43:78-85. doi: 10.1016/j.ijdevneu.2015.04.005. Epub 2015 Apr 15. PubMed PMID: 25889225.