WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 314212
CAS#: 863031-24-7 (potassium)
Description: Azilsartan medoxomil is a prodrug, is hydrolyzed to azilsartan in the gastrointestinal tract during absorption. Azilsartan is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan blocks the vasoconstrictor and aldosteronesecreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathway for angiotensin II synthesis.
MedKoo Cat#: 314212
Name: Azilsartan kamedoxomil
CAS#: 863031-24-7 (potassium)
Chemical Formula: C30H23KN4O8
Exact Mass:
Molecular Weight: 606.6323
Elemental Analysis: C, 59.40; H, 3.82; K, 6.45; N, 9.24; O, 21.10
Related CAS #: 863031-24-7 (potassium) 863031-21-4 (free acid)
Synonym: TAK-491; TAK 491; TAK491; Azilsartan Medoxomil; Azilsartan medoxomilpotassium; Azilsartan kamedoxomil; Brand name Edarbi.
IUPAC/Chemical Name: potassium 3-(4'-((2-ethoxy-7-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazol-4-ide
InChi Key: IHWFKDWIUSZLCJ-UHFFFAOYSA-M
InChi Code: InChI=1S/C30H24N4O8.K/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26;/h4-14H,3,15-16H2,1-2H3,(H,32,33,36);/q;+1/p-1
SMILES Code: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)[N-]5)C(=O)OCC6=C(OC(=O)O6)C.[K+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO.
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 606.6323 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Barrios V, Escobar C. Azilsartan medoxomil in the treatment of hypertension: the definitive angiotensin receptor blocker? Expert Opin Pharmacother. 2013 Nov;14(16):2249-61. doi: 10.1517/14656566.2013.834887. Epub 2013 Sep 26. Review. PubMed PMID: 24070321.
2: Angeli F, Verdecchia P, Pascucci C, Poltronieri C, Reboldi G. Pharmacokinetic evaluation and clinical utility of azilsartan medoxomil for the treatment of hypertension. Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):379-85. doi: 10.1517/17425255.2013.769521. Epub 2013 Feb 7. Review. PubMed PMID: 23387516.
3: Perry CM. Azilsartan medoxomil: a review of its use in hypertension. Clin Drug Investig. 2012 Sep 1;32(9):621-39. doi: 10.2165/11209600-000000000-00000. Review. PubMed PMID: 22877322.
4: Baker WL, White WB. Azilsartan medoxomil: a new angiotensin II receptor antagonist for treatment of hypertension. Ann Pharmacother. 2011 Dec;45(12):1506-15. doi: 10.1345/aph.1Q468. Epub 2011 Nov 24. Review. PubMed PMID: 22116996.
5: Zaiken K, Cheng JW. Azilsartan medoxomil: a new Angiotensin receptor blocker. Clin Ther. 2011 Nov;33(11):1577-89. doi: 10.1016/j.clinthera.2011.10.007. Epub 2011 Nov 8. Review. PubMed PMID: 22071238.
6: Vasiliou S. Azilsartan medoxomil for the treatment of hypertension. Drugs Today (Barc). 2011 Sep;47(9):647-51. doi: 10.1358/dot.2011.47.9.1688573. Review. PubMed PMID: 21971539.
