Avanafil
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 314211

CAS#: 330784-47-9

Description: Avanafil is a PDE5 inhibitor approved for erectile dysfunction by FDA on April 27, 2012 and by EMA on June 21, 2013. Avanafil is known by the trademark names Stendra and Spedra and was developed by Vivus Inc. Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina.


Chemical Structure

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Avanafil
CAS# 330784-47-9

Theoretical Analysis

MedKoo Cat#: 314211
Name: Avanafil
CAS#: 330784-47-9
Chemical Formula: C23H26ClN7O3
Exact Mass: 483.17857
Molecular Weight: 483.95064
Elemental Analysis: C, 57.08; H, 5.42; Cl, 7.33; N, 20.26; O, 9.92

Price and Availability

Size Price Availability Quantity
1.0g USD 450.0 2 Weeks
2.0g USD 850.0 2 Weeks
5.0g USD 1450.0 2 Weeks
10.0g USD 2650.0 2 Weeks
20.0g USD 3650.0 2 Weeks
50.0g USD 4650.0 2 Weeks
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Synonym: TA-1790; TA 1790; TA1790; Avanafil; trade name: Stendra; Spedra

IUPAC/Chemical Name: (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2pyrimidinylmethyl)-5-pyrimidinecarboxamide

InChi Key: WEAJZXNPAWBCOA-INIZCTEOSA-N

InChi Code: InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1

SMILES Code: O=C(C1=CN=C(N2[C@H](CO)CCC2)N=C1NCC3=CC=C(OC)C(Cl)=C3)NCC4=NC=CC=N4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO (10mg/mL)

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 483.95064 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Burke RM, Evans JD. Avanafil for treatment of erectile dysfunction: review of its potential. Vasc Health Risk Manag. 2012;8:517-23. doi: 10.2147/VHRM.S26712. Epub 2012 Aug 29. Review. PubMed PMID: 22973106; PubMed Central PMCID: PMC3433322.

2: Segal R, Burnett AL. Avanafil for the treatment of erectile dysfunction. Drugs Today (Barc). 2012 Jan;48(1):7-15. doi: 10.1358/dot.2012.48.1.1722068. Review. PubMed PMID: 22384456.

3: Alwaal A, Al-Mannie R, Carrier S. Future prospects in the treatment of erectile dysfunction: focus on avanafil. Drug Des Devel Ther. 2011;5:435-43. doi: 10.2147/DDDT.S15852. Epub 2011 Oct 18. Review. PubMed PMID: 22087063; PubMed Central PMCID: PMC3210072.

4: Limin M, Johnsen N, Hellstrom WJ. Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction. Expert Opin Investig Drugs. 2010 Nov;19(11):1427-37. doi: 10.1517/13543784.2010.518955. Epub 2010 Oct 13. Review. PubMed PMID: 20939743.