WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 314209
Description: Alcaftadine is used to prevent eye irritation brought on by allergic conjunctivitis. It is a H1 histamine receptor antagonist. It was approved by the U.S. Food and Drug Administration in 2010 under the trade name Lastacaft. Alcaftadine is an antagonist at three of the histamine receptors (1, 2 and 4). The main indication for Alcaftadine is for prevention of allergic conjunctivitis. By blocking these four receptors, Alcaftadine has been shown to significantly reduce the effects of allergens.
MedKoo Cat#: 314209
Chemical Formula: C19H21N3O
Exact Mass: 307.16846
Molecular Weight: 307.38954
Elemental Analysis: C, 74.24; H, 6.89; N, 13.67; O, 5.20
Alcaftadine purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: R89674; R 89674; R-89674; Alcaftadine; trade name: Lastacaft;
IUPAC/Chemical Name: 2-(1-Methylpiperidin-4-ylidene)-4,7-diazatricyclo[126.96.36.199(3,7)]tetradeca- 1(14),3,5,10,12-pentaene-6-carbaldehyde
InChi Key: MWTBKTRZPHJQLH-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3
SMILES Code: O=CC1=CN=C2/C(C3=CC=CC=C3CCN12)=C4CCN(C)CC/4
The following data is based on the product molecular weight 307.38954 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Mahvan TD, Buckley WA, Hornecker JR. Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1025-32. doi: 10.1345/aph.1Q755. Epub 2012 Jul 17. Review. PubMed PMID: 22811343.
2: Namdar R, Valdez C. Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc). 2011 Dec;47(12):883-90. doi: 10.1358/dot.2011.47.12.1709243. Review. PubMed PMID: 22348913.