Alcaftadine
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 314209

CAS#: 147084-10-4

Description: Alcaftadine is used to prevent eye irritation brought on by allergic conjunctivitis. It is a H1 histamine receptor antagonist. It was approved by the U.S. Food and Drug Administration in 2010 under the trade name Lastacaft. Alcaftadine is an antagonist at three of the histamine receptors (1, 2 and 4). The main indication for Alcaftadine is for prevention of allergic conjunctivitis. By blocking these four receptors, Alcaftadine has been shown to significantly reduce the effects of allergens.


Chemical Structure

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Alcaftadine
CAS# 147084-10-4

Theoretical Analysis

MedKoo Cat#: 314209
Name: Alcaftadine
CAS#: 147084-10-4
Chemical Formula: C19H21N3O
Exact Mass: 307.16846
Molecular Weight: 307.38954
Elemental Analysis: C, 74.24; H, 6.89; N, 13.67; O, 5.20

Price and Availability

Size Price Availability Quantity
25.0mg USD 280.0 2 Weeks
50.0mg USD 500.0 2 Weeks
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Synonym: R89674; R 89674; R-89674; Alcaftadine; trade name: Lastacaft;

IUPAC/Chemical Name: 2-(1-Methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0(3,7)]tetradeca- 1(14),3,5,10,12-pentaene-6-carbaldehyde

InChi Key: MWTBKTRZPHJQLH-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3

SMILES Code: O=CC1=CN=C2/C(C3=CC=CC=C3CCN12)=C4CCN(C)CC/4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 307.38954 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Mahvan TD, Buckley WA, Hornecker JR. Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1025-32. doi: 10.1345/aph.1Q755. Epub 2012 Jul 17. Review. PubMed PMID: 22811343.

2: Namdar R, Valdez C. Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc). 2011 Dec;47(12):883-90. doi: 10.1358/dot.2011.47.12.1709243. Review. PubMed PMID: 22348913.