WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406462

CAS#: 1086639-59-9

Description: Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3.

Chemical Structure

CAS# 1086639-59-9

Theoretical Analysis

MedKoo Cat#: 406462
Name: Y11
CAS#: 1086639-59-9
Chemical Formula: C8H17BrN4O
Exact Mass: 264.05857
Molecular Weight: 265.15078
Elemental Analysis: C, 36.24; H, 6.46; Br, 30.14; N, 21.13; O, 6.03

Size Price Shipping out time Quantity
5mg USD 245 2 Weeks
10mg USD 400 2 Weeks
25mg USD 680 2 Weeks
50mg USD 1045 2 Weeks
100mg USD 1525 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-06. Prices are subject to change without notice.

Y11, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: Y11; Y-11; Y 11

IUPAC/Chemical Name: (3r,5r,7r)-1-(2-hydroxyethyl)-1,3,5,7-tetraazaadamantan-1-ium bromide


InChi Code: InChI=1S/C8H17N4O.BrH/c13-2-1-12-6-9-3-10(7-12)5-11(4-9)8-12;/h13H,1-8H2;1H/q+1;/p-1

SMILES Code: OCC[N+]12C[N@]3C[N@](C2)C[N@](C3)C1.[Br-]

white solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 265.15078 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

 1. McLaughlin, Mark; Hazlehurst, Lori; Jain, Priyesh; Emmons, Michael F.; Gebhard, Anthony W.; Nair, Rajesh R. Preparation of peptides as integrin interaction inhibitors for the treatment of cancer.  PCT Int. Appl. (2013), WO 2013170066 A1 20131114.

Additional Information