WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406462
Description: Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3.
MedKoo Cat#: 406462
Chemical Formula: C8H17BrN4O
Exact Mass: 264.05857
Molecular Weight: 265.15078
Elemental Analysis: C, 36.24; H, 6.46; Br, 30.14; N, 21.13; O, 6.03
Synonym: Y11; Y-11; Y 11
IUPAC/Chemical Name: (3r,5r,7r)-1-(2-hydroxyethyl)-1,3,5,7-tetraazaadamantan-1-ium bromide.
SMILES Code: OCC[N+]12C[N@]3C[N@](C2)C[N@](C3)C1.[Br-]
1. McLaughlin, Mark; Hazlehurst, Lori; Jain, Priyesh; Emmons, Michael F.; Gebhard, Anthony W.; Nair, Rajesh R. Preparation of peptides as integrin interaction inhibitors for the treatment of cancer. PCT Int. Appl. (2013), WO 2013170066 A1 20131114.