WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406134
Description: XAV-939 is a Tankyrase (TNKS) inhibitor with potential anticancer activity. XAV-939 antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV-939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.
MedKoo Cat#: 406134
Chemical Formula: C14H11F3N2OS
Exact Mass: 312.05442
Molecular Weight: 312.31
Elemental Analysis: C, 53.84; H, 3.55; F, 18.25; N, 8.97; O, 5.12; S, 10.27
XAV-939, purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: XAV939; XAV 939; XAV-939.
IUPAC/Chemical Name: 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one
InChi Key: KLGQSVMIPOVQAX-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
SMILES Code: O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
The following data is based on the product molecular weight 312.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Distler A, Deloch L, Huang J, Dees C, Lin NY, Palumbo-Zerr K, Beyer C, Weidemann A, Distler O, Schett G, Distler JH. Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling. Ann Rheum Dis. 2012 Nov 12. [Epub ahead of print] PubMed PMID: 23148305.