WZ811
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MedKoo CAT#: 405250

CAS#: 55778-02-4

Description: WZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist. WZ811 shows subnanomolar potency (EC50 = 0.3 nM) in an affinity binding assay. In addition, when subjected to in vitro functional evaluation, WZ811 efficiently inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cyclic adenosine monophophate (cAMP) levels (EC50 = 1.2 nM) and SDF-1 induced Matrigel invasion (EC50 = 5.2 nM). The chemical structure of WZ811 is very similar to that of MSX-122.


Chemical Structure

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WZ811
CAS# 55778-02-4

Theoretical Analysis

MedKoo Cat#: 405250
Name: WZ811
CAS#: 55778-02-4
Chemical Formula: C18H18N4
Exact Mass: 290.15315
Molecular Weight: 290.36
Elemental Analysis: C, 74.46; H, 6.25; N, 19.30

Price and Availability

Size Price Availability Quantity
25.0mg USD 150.0 2 Weeks
50.0mg USD 250.0 2 Weeks
100.0mg USD 350.0 2 Weeks
200.0mg USD 550.0 2 Weeks
500.0mg USD 850.0 2 Weeks
1.0g USD 1450.0 2 Weeks
2.0g USD 2250.0 2 Weeks
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Synonym: WZ811; WZ-811; WZ 811.

IUPAC/Chemical Name: N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)

InChi Key: KBVFRXIGQQRMEF-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)

SMILES Code: C1(CNC2=NC=CC=C2)=CC=C(CNC3=NC=CC=C3)C=C1

Appearance: White solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 290.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kawatkar SP, Yan M, Gevariya H, Lim MY, Eisold S, Zhu X, Huang Z, An J. Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists. Exp Biol Med (Maywood). 2011 Jul 1;236(7):844-50. doi: 10.1258/ebm.2011.010345. Epub 2011 Jun 22. PubMed PMID: 21697335.

WZ811

25.0mg / USD 150.0


Additional Information

Related CAS#
55778-02-4 (WZ811 free base);
898190-81-3 (WZ811-2HCl salt);
897658-02-5(WZ811-4HCl salt)