WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406194
Description: WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP).
MedKoo Cat#: 406194
Chemical Formula: C18H15N3O3
Exact Mass: 321.11134
Molecular Weight: 321.33
Elemental Analysis: C, 67.28; H, 4.71; N, 13.08; O, 14.94
Synonym: WP1034; WP-1034; WP 1034
IUPAC/Chemical Name: (R,E)-2-cyano-3-(4-nitrophenyl)-N-(1-phenylethyl)acrylamide
InChi Key: RYYNDHCHTCVQJH-KWWJGWKXSA-N
InChi Code: InChI=1S/C18H15N3O3/c1-13(15-5-3-2-4-6-15)20-18(22)16(12-19)11-14-7-9-17(10-8-14)21(23)24/h2-11,13H,1H3,(H,20,22)/b16-11+/t13-/m1/s1
SMILES Code: O=C(N[C@@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=CC=C([N+]([O-])=O)C=C2
1: Faderl S, Ferrajoli A, Harris D, Van Q, Priebe W, Estrov Z. WP-1034, a novel JAK-STAT inhibitor, with proapoptotic and antileukemic activity in acute myeloid leukemia (AML). Anticancer Res. 2005 May-Jun;25(3B):1841-50. PubMed PMID: 16158916.