WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406353
CAS#: 872141-23-6
Description: WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.
MedKoo Cat#: 406353
Name: WAY-255348
CAS#: 872141-23-6
Chemical Formula: C16H14FN3O
Exact Mass: 283.11209
Molecular Weight: 283.3
Elemental Analysis: C, 67.83; H, 4.98; F, 6.71; N, 14.83; O, 5.65
This product is not in stock, which may be available by custom synthesis.
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Synonym: WAY255348; WAY-255348; WAY 255348.
IUPAC/Chemical Name: 5-(7-fluoro-3,3-dimethyl-2-oxoindolin-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile
InChi Key: KIOOLNRTWPFVHX-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14FN3O/c1-16(2)11-6-9(7-12(17)14(11)19-15(16)21)13-5-4-10(8-18)20(13)3/h4-7H,1-3H3,(H,19,21)
SMILES Code: N#CC1=CC=C(C2=CC3=C(NC(C3(C)C)=O)C(F)=C2)N1C
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs
Storage Condition: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Solubility: soluble in DMSO, not soluble in water.
Shelf Life: >2 years if stored properly.
Drug Formulation: this drug may be formulated in DMSO.
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 283.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Yudt MR, Russo LA, Berrodin TJ, Jelinsky SA, Ellis D, Cohen JC, Cooch N, Haglund E, Unwalla RJ, Fensome A, Wrobel J, Zhang Z, Nagpal S, Winneker RC. Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions. Biochem Pharmacol. 2011 Dec 1;82(11):1709-19. doi: 10.1016/j.bcp.2011.08.006. Epub 2011 Aug 11. PubMed PMID: 21854761.
