WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406306
CAS#: 17511-50-1
Description: UA8967 is a membrane-active anti-tumor agent. Cytotoxicity studies in six pancreatic cancer cell lines, one normal human pancreatic ductal epithelial line and two colon cancer cells showed the IC50s UA8967 ranged from 12–61 μM for exposure times of 72 h. There was also no selective inhibition of DNA, RNA or protein synthesis after exposure to UA8967. UA8967 is observed to affect the plasma membrane.
MedKoo Cat#: 406306
Name: UA8967
CAS#: 17511-50-1
Chemical Formula: C20H23N3
Exact Mass: 305.1892
Molecular Weight: 305.42
Elemental Analysis: C, 78.65; H, 7.59; N, 13.76
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Synonym: UA8967, UA8967, UA 8967
IUPAC/Chemical Name: 3-((4-benzylpiperazin-1-yl)methyl)-1H-indole
InChi Key: YHZKIEWEQQRAHY-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H23N3/c1-2-6-17(7-3-1)15-22-10-12-23(13-11-22)16-18-14-21-20-9-5-4-8-19(18)20/h1-9,14,21H,10-13,15-16H2
SMILES Code: C1(CN2CCN(CC3=CC=CC=C3)CC2)=CNC4=C1C=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 305.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Dorr RT, Samulitis BK, Wisner L, Han H, Zhao Y, Beroza P, Damodaran K, Igarashi S, Landowski TH, Von Hoff DD. Characterization of a membrane-active anti-tumor agent, UA8967. Invest New Drugs. 2013 Jun;31(3):576-86. doi: 10.1007/s10637-012-9901-z. Epub 2012 Nov 23. PubMed PMID: 23179338; PubMed Central PMCID: PMC3624034.
