SU5402
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406473

CAS#: 215543-92-3

Description: SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively).


Chemical Structure

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SU5402
CAS# 215543-92-3

Theoretical Analysis

MedKoo Cat#: 406473
Name: SU5402
CAS#: 215543-92-3
Chemical Formula: C17H16N2O3
Exact Mass: 296.11609
Molecular Weight: 296.32054
Elemental Analysis: C, 68.91; H, 5.44; N, 9.45; O, 16.20

Price and Availability

Size Price Availability Quantity
25.0mg USD 110.0 Ready to ship
50.0mg USD 190.0 Ready to ship
100.0mg USD 350.0 Ready to ship
200.0mg USD 550.0 Ready to ship
500.0mg USD 1150.0 Ready to ship
1.0g USD 2050.0 Ready to ship
2.0g USD 3650.0 Ready to ship
Bulk inquiry

Synonym: SU5402; SU-5402; SU 5402.

IUPAC/Chemical Name: (Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid.

InChi Key: JNDVEAXZWJIOKB-JYRVWZFOSA-N

InChi Code: InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-

SMILES Code: O=C(O)CCC1=C(/C=C2C(NC3=C\2C=CC=C3)=O)NC=C1C

Appearance: Orange solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF:PBS (pH 7.2) (1:1) 0.5 1.69

Preparing Stock Solutions

The following data is based on the product molecular weight 296.32054 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hu X, Zhang P, Xu Z, Chen H, Xie X. GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone. J Cell Biochem. 2013 Dec;114(12):2729-37. doi: 10.1002/jcb.24621. PubMed PMID: 23794283.

2: Nguyen TK, Tran VM, Sorna V, Eriksson I, Kojima A, Koketsu M, Loganathan D, Kjellén L, Dorsky RI, Chien CB, Kuberan B. Dimerized glycosaminoglycan chains increase FGF signaling during zebrafish development. ACS Chem Biol. 2013 May 17;8(5):939-48. doi: 10.1021/cb400132r. Epub 2013 May 7. PubMed PMID: 23614643.

3: Chang CH, Huang YL, Shyu MK, Chen SU, Lin CH, Ju TK, Lu J, Lee H. Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. Acta Pharmacol Sin. 2013 Mar;34(3):360-6. doi: 10.1038/aps.2012.186. Epub 2013 Feb 4. PubMed PMID: 23377549.

4: Sun N, Zou H, Yang L, Morita K, Gong P, Shiba T, Akagawa Y, Yuan Q. Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway. Biochem Biophys Res Commun. 2012 Nov 16;428(2):298-302. doi: 10.1016/j.bbrc.2012.10.051. Epub 2012 Oct 18. PubMed PMID: 23085229.

5: Bojesen KB, Clausen O, Rohde K, Christensen C, Zhang L, Li S, Køhler L, Nielbo S, Nielsen J, Gjørlund MD, Poulsen FM, Bock E, Berezin V. Nectin-1 binds and signals through the fibroblast growth factor receptor. J Biol Chem. 2012 Oct 26;287(44):37420-33. doi: 10.1074/jbc.M112.345215. Epub 2012 Sep 5. PubMed PMID: 22955284; PubMed Central PMCID: PMC3481338.

6: Xiao L, Esliger A, Hurley MM. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res. 2013 Jan;28(1):35-45. doi: 10.1002/jbmr.1721. PubMed PMID: 22836867; PubMed Central PMCID: PMC3519956.

7: Elsayed M, Banasr M, Duric V, Fournier NM, Licznerski P, Duman RS. Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression. Biol Psychiatry. 2012 Aug 15;72(4):258-65. doi: 10.1016/j.biopsych.2012.03.003. Epub 2012 Apr 17. PubMed PMID: 22513055; PubMed Central PMCID: PMC3401338.

8: Zhang K, Ealy AD. Disruption of fibroblast growth factor receptor signaling in bovine cumulus-oocyte complexes during in vitro maturation reduces subsequent embryonic development. Domest Anim Endocrinol. 2012 May;42(4):230-8. doi: 10.1016/j.domaniend.2011.12.006. Epub 2012 Jan 10. PubMed PMID: 22264662.

9: Shiota M, Hikita Y, Kawamoto Y, Kusakabe H, Tanaka M, Izumi Y, Nakao T, Miura K, Funae Y, Iwao H. Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2. J Cell Mol Med. 2012 Sep;16(9):2001-9. doi: 10.1111/j.1582-4934.2011.01494.x. PubMed PMID: 22117815.

10: Sharma R, George A, Kamble NM, Singh KP, Chauhan MS, Singla SK, Manik RS, Palta P. Optimization of culture conditions to support long-term self-renewal of buffalo (Bubalus bubalis) embryonic stem cell-like cells. Cell Reprogram. 2011 Dec;13(6):539-49. doi: 10.1089/cell.2011.0041. Epub 2011 Oct 26. PubMed PMID: 22029416.

SU5402

25.0mg / USD 110.0


Additional Information