SLR080811 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406468

CAS#: 1449768-36-8 (HCl)

Description: SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.

Chemical Structure

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SLR080811 HCl
CAS# 1449768-36-8 (HCl)
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 406468
Name: SLR080811 HCl
CAS#: 1449768-36-8 (HCl)
Chemical Formula: C21H31N5O
Exact Mass: 369.25286
Molecular Weight: 369.50374
Elemental Analysis: C, 68.26; H, 8.46; N, 18.95; O, 4.33

Size Price Shipping out time Quantity
Inquire bulk and customized quantity
Pricing updated 2021-03-08. Prices are subject to change without notice.

SLR080811 HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Related CAS #: 1449768-36-8 (HCl)   1449765-65-4 (free base)    

Synonym: SLR080811; SLR080811; SLR 080811.

IUPAC/Chemical Name: (R)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride

InChi Key: SHNUYJZAJHWURD-GMUIIQOCSA-N

InChi Code: InChI=1S/C21H31N5O.ClH/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23;/h11-14,18H,2-10,15H2,1H3,(H3,22,23);1H/t18-;/m1./s1

SMILES Code: N=C(N1[C@@H](C2=NC(C3=CC=C(CCCCCCCC)C=C3)=NO2)CCC1)N.[H]Cl

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 369.50374 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Yugesh Kharel*1, Mithun Raje†1, Ming Gao†, Amanda M. Gellett*, Jose L. Tomsig*, Kevin R. Lynch*1,2 and Webster L. Santos†1,2Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.  Biochem. J. (2012) 447 (149–157) (Printed in Great Britain) doi:10.1042/BJ20120609.

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SLR080811 HCl



Additional Information