WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406468
CAS#: 1449768-36-8 (HCl)
Description: SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.
MedKoo Cat#: 406468
Name: SLR080811 HCl
CAS#: 1449768-36-8 (HCl)
Chemical Formula: C21H31N5O
Exact Mass: 369.25286
Molecular Weight: 369.50374
Elemental Analysis: C, 68.26; H, 8.46; N, 18.95; O, 4.33
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 1449768-36-8 (HCl) 1449765-65-4 (free base)
Synonym: SLR080811; SLR080811; SLR 080811.
IUPAC/Chemical Name: (R)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride
InChi Key: SHNUYJZAJHWURD-GMUIIQOCSA-N
InChi Code: InChI=1S/C21H31N5O.ClH/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23;/h11-14,18H,2-10,15H2,1H3,(H3,22,23);1H/t18-;/m1./s1
SMILES Code: N=C(N1[C@@H](C2=NC(C3=CC=C(CCCCCCCC)C=C3)=NO2)CCC1)N.[H]Cl
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 369.50374 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Yugesh Kharel*1, Mithun Raje†1, Ming Gao†, Amanda M. Gellett*, Jose L. Tomsig*, Kevin R. Lynch*1,2 and Webster L. Santos†1,2Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. Biochem. J. (2012) 447 (149–157) (Printed in Great Britain) doi:10.1042/BJ20120609.
