SLR080811 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406468

CAS#: 1449768-36-8 (HCl)

Description: SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.

Chemical Structure

SLR080811 HCl
CAS# 1449768-36-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 406468
Name: SLR080811 HCl
CAS#: 1449768-36-8 (HCl)
Chemical Formula: C21H31N5O
Exact Mass: 369.25286
Molecular Weight: 369.50374
Elemental Analysis: C, 68.26; H, 8.46; N, 18.95; O, 4.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1449768-36-8 (HCl)   1449765-65-4 (free base)    

Synonym: SLR080811; SLR080811; SLR 080811.

IUPAC/Chemical Name: (R)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride


InChi Code: InChI=1S/C21H31N5O.ClH/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23;/h11-14,18H,2-10,15H2,1H3,(H3,22,23);1H/t18-;/m1./s1


Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 369.50374 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Yugesh Kharel*1, Mithun Raje†1, Ming Gao†, Amanda M. Gellett*, Jose L. Tomsig*, Kevin R. Lynch*1,2 and Webster L. Santos†1,2Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.  Biochem. J. (2012) 447 (149–157) (Printed in Great Britain) doi:10.1042/BJ20120609.

Additional Information