WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406167
Description: SCH-1473759 is a potent and selective Aurora A/B inhibitor with IC50 sub-nanomolar. SCH 1473759 was active against a large panel of tumor cell lines from different tissue origin and genetic backgrounds. SCH-1473759 demonstrated potent mechanism-based activity, and activity was shown to be enhanced in combination with taxanes and KSP inhibitors. This information may be useful for optimizing the clinical efficacy of Aurora inhibitors.
MedKoo Cat#: 406167
Chemical Formula: C20H26N8OS
Exact Mass: 426.19503
Molecular Weight: 426.53844
Elemental Analysis: C, 56.32; H, 6.14; N, 26.27; O, 3.75; S, 7.52
Related CAS #: 1094069-99-4 (free base) 1094067-13-6 (HCl)
Synonym: SCH1473759; SCH-1473759; SCH 1473759.
IUPAC/Chemical Name: 2-(ethyl((5-((6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol
SMILES Code: CC(C)(N(CC)CC1=NSC(NC2=NC(C)=CN3C2=NC=C3C4=CNN=C4)=C1)CO
1: Basso AD, Liu M, Gray K, Tevar S, Lee S, Liang L, Ponery A, Smith EB, Monsma FJ Jr, Yu T, Zhang Y, Kerekes AD, Esposite S, Xiao Y, Tagat JR, Hicklin DJ, Kirschmeier P. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33. doi: 10.1007/s00280-011-1568-1. Epub 2011 Feb 5. PubMed PMID: 21298383.