We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406225

CAS#: 104408-38-0

Description: SC-44463 is an MMP inhibitor, also a collagenase inhibitor , and HDAC inhibitor.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-05-29. Prices are subject to change without notice.

SC-44463 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 406225
Name: SC-44463
CAS#: 104408-38-0
Chemical Formula: C19H29N3O5
Exact Mass: 379.21072
Molecular Weight: 379.45
Elemental Analysis: C, 60.14; H, 7.70; N, 11.07; O, 21.08

Synonym: SC44463; SC44463; SC 44463.

IUPAC/Chemical Name: (R)-N4-hydroxy-2-isobutyl-N1-((S)-3-(4-methoxyphenyl)-1-(methylamino)-1-oxopropan-2-yl)succinamide


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information



1: Holliday LS, Vakani A, Archer L, Dolce C. Effects of matrix metalloproteinase inhibitors on bone resorption and orthodontic tooth movement. J Dent Res. 2003 Sep;82(9):687-91. PubMed PMID: 12939351.

2: Cornelius LA, Nehring LC, Harding E, Bolanowski M, Welgus HG, Kobayashi DK, Pierce RA, Shapiro SD. Matrix metalloproteinases generate angiostatin: effects on neovascularization. J Immunol. 1998 Dec 15;161(12):6845-52. PubMed PMID: 9862716.

3: Dunsmore SE, Saarialho-Kere UK, Roby JD, Wilson CL, Matrisian LM, Welgus HG, Parks WC. Matrilysin expression and function in airway epithelium. J Clin Invest. 1998 Oct 1;102(7):1321-31. PubMed PMID: 9769324; PubMed Central PMCID: PMC508979.

4: Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL. Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem. 1997 Aug 29;272(35):22053-8. PubMed PMID: 9268345.

5: Sawicki G, Salas E, Murat J, Miszta-Lane H, Radomski MW. Release of gelatinase A during platelet activation mediates aggregation. Nature. 1997 Apr 10;386(6625):616-9. PubMed PMID: 9121586.

6: Mitchell PG, Lopresti-Morrow L, Yocum SA, Sweeney FJ, Reiter LA. Inhibition of interleukin-1-stimulated collagen degradation in cartilage explants. Ann N Y Acad Sci. 1994 Sep 6;732:395-7. PubMed PMID: 7978818.

7: Zhang D, Botos I, Gomis-Rüth FX, Doll R, Blood C, Njoroge FG, Fox JW, Bode W, Meyer EF. Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d). Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8447-51. PubMed PMID: 8078901; PubMed Central PMCID: PMC44623.

8: Boghaert ER, Chan SK, Zimmer C, Grobelny D, Galardy RE, Vanaman TC, Zimmer SG. Inhibition of collagenolytic activity relates to quantitative reduction of invasion in vitro in a c-Ha-ras transfected glial cell line. J Neurooncol. 1994;21(2):141-50. PubMed PMID: 7861190.

9: Butler TA, Zhu C, Mueller RA, Fuller GC, Lemaire WJ, Woessner JF Jr. Inhibition of ovulation in the perfused rat ovary by a synthetic collagenase inhibitor. Matrix Suppl. 1992;1:400-1. PubMed PMID: 1480072.

10: Fini ME, Cui TY, Mouldovan A, Grobelny D, Galardy RE, Fisher SJ. An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epithelium. Invest Ophthalmol Vis Sci. 1991 Oct;32(11):2997-3001. PubMed PMID: 1655675