RB-005

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406471

CAS#: 1425049-20-2

Description: RB-005 is a potent sphingosine kinase isoform 1 (SK1) inhibitor, which may serve as therapeutic agent for proliferative diseases, including hypertension. RB-005, (IC(50) = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.

Chemical Structure

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RB-005
CAS# 1425049-20-2
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 406471
Name: RB-005
CAS#: 1425049-20-2
Chemical Formula: C21H35NO
Exact Mass: 317.27186
Molecular Weight: 317.5087
Elemental Analysis: C, 79.44; H, 11.11; N, 4.41; O, 5.04

Size Price Shipping out time Quantity
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Pricing updated 2021-03-07. Prices are subject to change without notice.

RB005 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: RB005; RB 005; RB-005.

IUPAC/Chemical Name: 1-(4-octylphenethyl)piperidin-4-ol

InChi Key: PXLXLCZHGHRZAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H35NO/c1-2-3-4-5-6-7-8-19-9-11-20(12-10-19)13-16-22-17-14-21(23)15-18-22/h9-12,21,23H,2-8,13-18H2,1H3

SMILES Code: OC1CCN(CCC2=CC=C(CCCCCCCC)C=C2)CC1

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 317.5087 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Baek DJ, MacRitchie N, Anthony NG, Mackay SP, Pyne S, Pyne NJ, Bittman R. Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. J Med Chem. 2013 Nov 27;56(22):9310-27. doi: 10.1021/jm401399c. Epub 2013 Nov 14. PubMed PMID: 24164513; PubMed Central PMCID: PMC3848335.

2: Baek DJ, MacRitchie N, Pyne NJ, Pyne S, Bittman R. Synthesis of selective inhibitors of sphingosine kinase 1. Chem Commun (Camb). 2013 Mar 14;49(21):2136-8. doi: 10.1039/c3cc00181d. Epub 2013 Feb 7. PubMed PMID: 23388656; PubMed Central PMCID: PMC3608193.

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RB-005



Additional Information