WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406471
Description: RB-005 is a potent sphingosine kinase isoform 1 (SK1) inhibitor, which may serve as therapeutic agent for proliferative diseases, including hypertension. RB-005, (IC(50) = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.
MedKoo Cat#: 406471
Chemical Formula: C21H35NO
Exact Mass: 317.27186
Molecular Weight: 317.5087
Elemental Analysis: C, 79.44; H, 11.11; N, 4.41; O, 5.04
RB005 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: RB005; RB 005; RB-005.
IUPAC/Chemical Name: 1-(4-octylphenethyl)piperidin-4-ol
InChi Key: PXLXLCZHGHRZAO-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H35NO/c1-2-3-4-5-6-7-8-19-9-11-20(12-10-19)13-16-22-17-14-21(23)15-18-22/h9-12,21,23H,2-8,13-18H2,1H3
SMILES Code: OC1CCN(CCC2=CC=C(CCCCCCCC)C=C2)CC1
The following data is based on the product molecular weight 317.5087 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Baek DJ, MacRitchie N, Anthony NG, Mackay SP, Pyne S, Pyne NJ, Bittman R. Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. J Med Chem. 2013 Nov 27;56(22):9310-27. doi: 10.1021/jm401399c. Epub 2013 Nov 14. PubMed PMID: 24164513; PubMed Central PMCID: PMC3848335.
2: Baek DJ, MacRitchie N, Pyne NJ, Pyne S, Bittman R. Synthesis of selective inhibitors of sphingosine kinase 1. Chem Commun (Camb). 2013 Mar 14;49(21):2136-8. doi: 10.1039/c3cc00181d. Epub 2013 Feb 7. PubMed PMID: 23388656; PubMed Central PMCID: PMC3608193.