BGB324 (R428)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 401810

CAS#: 1037624-75-1

Description: BGB-324, also known as R428 or Bemcentinib, is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production.


Price and Availability

Size
Price

5mg
USD 150
50mg
USD 650
500mg
USD 3450
Size
Price

10mg
USD 250
100mg
USD 950
1g
USD 4950
Size
Price

25mg
USD 450
200mg
USD 1950
2g
USD 7650

BGB324 (R428) purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 300mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 401810
Name: BGB324 (R428)
CAS#: 1037624-75-1
Chemical Formula: C30H34N8
Exact Mass: 506.29064
Molecular Weight: 506.64
Elemental Analysis: C, 71.12; H, 6.76; N, 22.12


Synonym: BGB324 ; BGB-324 ; BGB 324 ; R 428 R 428 R428; Bemcentinib

IUPAC/Chemical Name: (S)-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine

InChi Key: KXMZDGSRSGHMMK-VWLOTQADSA-N

InChi Code: InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1

SMILES Code: NC1=NC(NC2=CC=C3C(CC[C@@H](N4CCCC4)CC3)=C2)=NN1C5=NN=C6C(CCCC7=CC=CC=C76)=C5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Hector A, Montgomery EA, Karikari C, Canto M, Dunbar KB, Wang JS, Feldmann G, Hong SM, Haffner MC, Meeker AK, Holland SJ, Yu J, Heckrodt TJ, Zhang J, Ding P, Goff D, Singh R, Roa JC, Marimuthu A, Riggins GJ, Eshleman JR, Nelkin BD, Pandey A, Maitra A. The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma. Cancer Biol Ther. 2010 Nov;10(10):1009-18. Epub 2010 Nov 15. PubMed PMID: 20818175; PubMed Central PMCID: PMC3025816.

2: Smolock EM, Korshunov VA. Pharmacological inhibition of Axl affects smooth muscle cell functions under oxidative stress. Vascul Pharmacol. 2010 Sep-Oct;53(3-4):185-92. Epub 2010 Jul 16. PubMed PMID: 20643227.

3: Holland SJ, Pan A, Franci C, Hu Y, Chang B, Li W, Duan M, Torneros A, Yu J, Heckrodt TJ, Zhang J, Ding P, Apatira A, Chua J, Brandt R, Pine P, Goff D, Singh R, Payan DG, Hitoshi Y. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54. Epub 2010 Feb 9. PubMed PMID: 20145120.