WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406460
Description: QL47, also known as QL-XII-47, is a potent and selective BTK inhibitor, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations.
MedKoo Cat#: 406460
Chemical Formula: C27H21N5O2
Exact Mass: 447.16952
Molecular Weight: 447.48794
Elemental Analysis: C, 72.47; H, 4.73; N, 15.65; O, 7.15
QL47 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: QL47; QL 47; QL47. QL-XII-47
IUPAC/Chemical Name: 1-(1-acryloylindolin-6-yl)-9-(1-methyl-1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2(1H)-one
InChi Key: RTRNJQOBEOISFQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3
SMILES Code: O=C1N(C2=CC3=C(C=C2)CCN3C(C=C)=O)C4=C(C=NC5=CC=C(C6=CN(C)N=C6)C=C54)C=C1
The following data is based on the product molecular weight 447.48794 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wu H, Wang W, Liu F, Weisberg EE, Tian B, Chen Y, Li B, Wang A, Wang B, Zhao Z, McMillin DW, Hu C, Li H, Wang J, Liang Y, Buhrlage SJ, Liang J, Liu J, Yang G, Brwon JR, Treon SP, Mitsiades CS, Griffin J, Liu Q, Gray NS. Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma. ACS Chem Biol. 2014 Feb 20. [Epub ahead of print] PubMed PMID: 24556163.