WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406729
CAS#: NONE
Description: PTX013 is a potent, cytotoxic anti-tumor agents. PTX013 is particularly effective at inhibiting the growth of several human cancer cell lines, as well as drug resistant cancer cells. Mechanistically, PTX013 induces cell cycle arrest in sub-G1 and G0/G1 phases of e.g. SQ20B cells, a radio-resistant human head and neck carcinoma model. In the syngeneic B16F10 melanoma tumor mouse model, PTX013 (0.5 mg/Kg) inhibits tumor growth by about 50-fold better than parent PTX008.
MedKoo Cat#: 406729
Name: PTX-013 HCl
CAS#: NONE
Chemical Formula: C44H64Cl4N4O4
Exact Mass: 708.46146
Molecular Weight: 854.82
Elemental Analysis: C, 61.82; H, 7.55; Cl, 16.59; N, 6.55; O, 7.49
This product is not in stock, which may be available by custom synthesis.
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Synonym: PTX013; PTX-013; PTX 013; PTX-013 tetrahydrochloride; PTX-013 HCl
IUPAC/Chemical Name: 2,2',2'',2'''-(1,3,5,7(1,3)-tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N,N-dimethylethan-1-amine) tetrahydrochloride
InChi Key: LSGLYQIMNJNTPV-UHFFFAOYSA-N
InChi Code: InChI=1S/C44H60N4O4.4ClH/c1-45(2)21-25-49-41-33-13-9-14-34(41)30-36-16-11-18-38(43(36)51-27-23-47(5)6)32-40-20-12-19-39(44(40)52-28-24-48(7)8)31-37-17-10-15-35(29-33)42(37)50-26-22-46(3)4;;;;/h9-20H,21-32H2,1-8H3;4*1H
SMILES Code: CN(C)CCOC1=C2C=CC=C1CC3=CC=CC(CC4=CC=CC(CC5=CC=CC(C2)=C5OCCN(C)C)=C4OCCN(C)C)=C3OCCN(C)C.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs
Storage Condition: 0 – 4 oC for short term (weeks to 1 month) or -20 oC for long terms (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly.
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 854.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Dings RP, Levine JI, Brown SG, Astorgues-Xerri L, MacDonald JR, Hoye TR, Raymond E, Mayo KH. Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer. Invest New Drugs. 2013 Oct;31(5):1142-50. doi: 10.1007/s10637-013-9932-0. Epub 2013 Feb 8. PubMed PMID: 23392775.
