PP121
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 401708

CAS#: 1092788-83-4

Description: PP121 is a multitargeted dual receptor tyrosine kinases inhibitor. PP121 blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and phosphatidylinositol-3-OH kinases.


Chemical Structure

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PP121
CAS# 1092788-83-4

Theoretical Analysis

MedKoo Cat#: 401708
Name: PP121
CAS#: 1092788-83-4
Chemical Formula: C17H17N7
Exact Mass: 319.15
Molecular Weight: 319.360
Elemental Analysis: C, 63.93; H, 5.37; N, 30.70

Price and Availability

Size Price Availability Quantity
5mg USD 280 2 Weeks
10mg USD 520 2 Weeks
25mg USD 870 2 Weeks
50mg USD 1200 2 Weeks
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Synonym: PP121; PP 121; PP121

IUPAC/Chemical Name: 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

InChi Key: NVRXTLZYXZNATH-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)

SMILES Code: NC1=C2C(N(C3CCCC3)N=C2C4=CN=C(NC=C5)C5=C4)=NC=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 20.0 62.63
DMSO 10.0 31.31
Ethanol 0.5 1.57

Preparing Stock Solutions

The following data is based on the product molecular weight 319.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R,  Williams RL, Shokat KM, Knight ZA. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. Epub 2008 Oct 12. PubMed PMID: 18849971; PubMed Central PMCID: PMC2880455.