WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406450
CAS#: 1239513-63-3
Description: Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc.
MedKoo Cat#: 406450
Name: Poloxipan
CAS#: 1239513-63-3
Chemical Formula: C14H10BrN3O3S
Exact Mass: 378.96262
Molecular Weight: 380.2165
Elemental Analysis: C, 44.22; H, 2.65; Br, 21.02; N, 11.05; O, 12.62; S, 8.43
This product is not in stock, which may be available by custom synthesis.
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Synonym: Poloxipan
IUPAC/Chemical Name: (Z)-2-(5-bromo-2-methoxybenzylidene)-6-methyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione
InChi Key: UEMYVTYHECWXSR-WDZFZDKYSA-N
InChi Code: InChI=1S/C14H10BrN3O3S/c1-7-12(19)16-14-18(17-7)13(20)11(22-14)6-8-5-9(15)3-4-10(8)21-2/h3-6H,1-2H3/b11-6-
SMILES Code: O=C(N(C1=N2)N=C(C)C2=O)/C(S1)=C/C3=CC(Br)=CC=C3OC
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 380.2165 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Reindl W, Yuan J, Krämer A, Strebhardt K, Berg T. A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis. Chembiochem. 2009 May 4;10(7):1145-8. doi: 10.1002/cbic.200900059. PubMed PMID: 19350612.
