Poloxipan

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406450

CAS#: 1239513-63-3

Description: Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc.


Chemical Structure

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Poloxipan
CAS# 1239513-63-3

Theoretical Analysis

MedKoo Cat#: 406450
Name: Poloxipan
CAS#: 1239513-63-3
Chemical Formula: C14H10BrN3O3S
Exact Mass: 378.96262
Molecular Weight: 380.2165
Elemental Analysis: C, 44.22; H, 2.65; Br, 21.02; N, 11.05; O, 12.62; S, 8.43

Size Price Shipping out time Quantity
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Pricing updated 2021-03-08. Prices are subject to change without notice.

Poloxipan is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: Poloxipan

IUPAC/Chemical Name: (Z)-2-(5-bromo-2-methoxybenzylidene)-6-methyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione

InChi Key: UEMYVTYHECWXSR-WDZFZDKYSA-N

InChi Code: InChI=1S/C14H10BrN3O3S/c1-7-12(19)16-14-18(17-7)13(20)11(22-14)6-8-5-9(15)3-4-10(8)21-2/h3-6H,1-2H3/b11-6-

SMILES Code: O=C(N(C1=N2)N=C(C)C2=O)/C(S1)=C/C3=CC(Br)=CC=C3OC

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 380.2165 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Reindl W, Yuan J, Krämer A, Strebhardt K, Berg T. A pan-specific inhibitor of  the polo-box domains of polo-like kinases arrests cancer cells in mitosis. Chembiochem. 2009 May 4;10(7):1145-8. doi: 10.1002/cbic.200900059. PubMed PMID: 19350612.



Additional Information