WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406450
Description: Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc.
MedKoo Cat#: 406450
Chemical Formula: C14H10BrN3O3S
Exact Mass: 378.96262
Molecular Weight: 380.2165
Elemental Analysis: C, 44.22; H, 2.65; Br, 21.02; N, 11.05; O, 12.62; S, 8.43
Poloxipan is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
IUPAC/Chemical Name: (Z)-2-(5-bromo-2-methoxybenzylidene)-6-methyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione
InChi Key: UEMYVTYHECWXSR-WDZFZDKYSA-N
InChi Code: InChI=1S/C14H10BrN3O3S/c1-7-12(19)16-14-18(17-7)13(20)11(22-14)6-8-5-9(15)3-4-10(8)21-2/h3-6H,1-2H3/b11-6-
SMILES Code: O=C(N(C1=N2)N=C(C)C2=O)/C(S1)=C/C3=CC(Br)=CC=C3OC
The following data is based on the product molecular weight 380.2165 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Reindl W, Yuan J, KrÃ¤mer A, Strebhardt K, Berg T. A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis. Chembiochem. 2009 May 4;10(7):1145-8. doi: 10.1002/cbic.200900059. PubMed PMID: 19350612.